For a study, researchers sought to find how depression affected asthmatic patients’ mortality among adults in the United States. The National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2014 were used in this observational investigation. The Patient Health Questionnaire-9 was used to assess depression (PHQ-9). Investigators estimated hazard ratios (HRs) with 95% CIs for the link between depression and all-cause mortality using survey-weighted Cox proportional hazard models. The study comprised a total of 1,865 asthmatic individuals. About 264 (14.16%) of them exhibited depressive symptoms. There were 24 (9.1%) fatalities in 264 patients with depression throughout the 9970 person-years of follow-up, compared to 100 (6.3%) deaths in 1,601 individuals without depression. Depression was linked to an increased risk of all-cause death in unadjusted models (HR, 2.22 [95% CI 1.32–3.73]). The link remained after controlling for age, gender, race/ethnicity, and BMI (HR, 2.71 [95% CI 1.58–4.66]). However, the study group found no significant link between depression and death (HR, 1.92 [95% CI 0.82–4.45]). Subgroup analysis revealed that depression was an independent risk factor for mortality only in females (HR, 3.78 [95% CI 1.17, 12.26]) but not in all asthmatic patients. According to the results, the depressive condition was widespread in asthmatic patients, and depression was linked to a greater mortality rate in asthmatic patients. In female patients, depression was an independent risk factor for death.

Source:aacijournal.biomedcentral.com/articles/10.1186/s13223-022-00672-4

Author