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Association between E/e´ ratio and fluid overload in patients with predialysis chronic kidney disease.

Association between E/e´ ratio and fluid overload in patients with predialysis chronic kidney disease.
Author Information (click to view)

Kim JS, Yang JW, Yoo JS, Choi SO, Han BG,


Kim JS, Yang JW, Yoo JS, Choi SO, Han BG, (click to view)

Kim JS, Yang JW, Yoo JS, Choi SO, Han BG,

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PloS one 2017 09 1312(9) e0184764 doi 10.1371/journal.pone.0184764
Abstract
BACKGROUND
Chronic fluid overload is common in patients with chronic kidney disease (CKD) and can with time lead to diastolic dysfunction and heart failure. We investigated whether markers of fluid status, such as NT-proBNP and bioimpedance spectroscopy (BIS), can predict echocardiographic findings of diastolic dysfunction in non-dialysis CKD5 patients.

METHODS
BIS, echocardiography, and measurement of serum NT-proBNP were performed in patients with non-dialysis CKD stage 5 at a single study visit. E/e´ ratio reflect mean LV diastolic pressure and a ratio greater than 15 was used as a definition of diastolic dysfunction.

RESULTS
Eighty-four patients were analyzed. Forty-six patients (54.76%) had E/e´ ratio ≤15 and 38 patients (45.24%) had E/e´ > 15 (diastolic dysfunction). Patients with E/e´>15 had significantly higher serum NT-proBNP (14,650 pg/mL) than patients with to E/e´≤15 (4,271 pg/mL) and had more overhydration (OH), 5.1 liters compared to 2.4 liters. The cut-off values predicting diastolic dysfunction were found to be 2,797 pg/mL for NT-proBNP and 2.45 liters for OH.

CONCLUSIONS
Regular monitoring of fluid status by BIS and NT-proBNP can be used to find patient with risk of developing diastolic dysfunction. Treatments to correct fluid overload may reduce the risk of developing diastolic dysfunction and improve cardiovascular outcome in patients with CKD.

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