MRD is the condition where the neoplastic cells evade detection during cytomorphologic analysis. Patients with AML and MRD might need better prognostications. Thus, this study aims at finding the association between MRD, DFS – disease-free survival, and OS – overall survival, and AML.

The study uses scientific literature procured from clinical studies published on MEDLINE, PubMed, and Embase. The researchers used meta-analysis and systematic review guidelines to screen the papers and chose studies that concerned OS or DFS association with AML individuals’ MRD status. The study used the Bayesian hierarchical modeling method.

The average hazard ratio (HR) for those with MRD negative was 0.36 for OS and 0.37 for DFS. 5-year estimated DFS for those with negative MRD was 64% and 25% for individuals with MRD. For those with negative MRD, the estimated overall survival was 68% and 34% for MRD subjects. There was a significant association between MRD negativity and OS/DFS, except in those with MRD assessed by fluorescents in-situ hybridization or cytogenetics.

The study proved that negative MRD has a significant association with superior OS and DFS in individuals with AML. The MRD negativity value seems constant in all subgroups, MRD detection methods, time of assessment, and age groups.

Ref: https://jamanetwork.com/journals/jamaoncology/article-abstract/2771199