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Association between Smoking and Glycemic Control in Diabetic Patients: Results from the REACTION study.

Association between Smoking and Glycemic Control in Diabetic Patients: Results from the REACTION study.
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Peng K, Chen G, Liu C, Mu Y, Ye Z, Shi L, Zhao J, Chen L, Li Q, Yang T, Yan L, Wan Q, Wu S, Wang G, Luo Z, Tang X, Huo Y, Gao Z, Su Q, Wang Y, Qin G, Deng H, Yu X, Shen F, Chen L, Zhao L, Xu Y, Xu M, Chen Y, Lu J, Lin L, Du R, Dai M, Li M, Wang T, Zhao Z, Zhang D, Bi Y, Li D, Wang W, Ning G, ,


Peng K, Chen G, Liu C, Mu Y, Ye Z, Shi L, Zhao J, Chen L, Li Q, Yang T, Yan L, Wan Q, Wu S, Wang G, Luo Z, Tang X, Huo Y, Gao Z, Su Q, Wang Y, Qin G, Deng H, Yu X, Shen F, Chen L, Zhao L, Xu Y, Xu M, Chen Y, Lu J, Lin L, Du R, Dai M, Li M, Wang T, Zhao Z, Zhang D, Bi Y, Li D, Wang W, Ning G, , (click to view)

Peng K, Chen G, Liu C, Mu Y, Ye Z, Shi L, Zhao J, Chen L, Li Q, Yang T, Yan L, Wan Q, Wu S, Wang G, Luo Z, Tang X, Huo Y, Gao Z, Su Q, Wang Y, Qin G, Deng H, Yu X, Shen F, Chen L, Zhao L, Xu Y, Xu M, Chen Y, Lu J, Lin L, Du R, Dai M, Li M, Wang T, Zhao Z, Zhang D, Bi Y, Li D, Wang W, Ning G, ,

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Journal of diabetes 2017 11 16() doi 10.1111/1753-0407.12625
Abstract
BACKGROUND
A number of primary studies suggested that active smoking could be independently associated with incident diabetes. However less is known about the impact of active smoking and smoking cessation on glycemic control in patients with diabetes. We aimed to evaluate the associations of active smoking and smoking cessation with glycemic control in diabetic patients.

METHODS
This is a cross-sectional study of 10,551 man and 15,297 women with diabetes from the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study. Risk factors for glycemic control and the association of active smoking with glycemic control were evaluated using logistic regression models. Hemoglobin A1c (HbA1c) ≥7.0% was defined as poor glycemic control.

RESULTS
Current smokers have increased risk for poor glycemic control, and the multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) of HbA1c≥7.0% with current smoking were 1.49 (1.35-1.66) in men and 1.56 (1.13-2.15) in women. Further analysis demonstrated a dose-response relationship between active smoking and the risk of poor glycemic control in men. Former smokers who quit smoking for <10 years remained at increased risk for poor glycemic control, and the risk leveled off after 10 years of smoking cessation compared with non-smokers, while the risk was significantly decreased compared with current smokers. CONCLUSIONS
Active smoking is a modifiable risk factor for poor glycemic control in Chinese diabetic patients.

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