Advertisement

 

 

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis.

Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis.
Author Information (click to view)

Zhang J, Sun X, Wang J, Zhang F, Li X, Han J,


Zhang J, Sun X, Wang J, Zhang F, Li X, Han J, (click to view)

Zhang J, Sun X, Wang J, Zhang F, Li X, Han J,

Advertisement

PloS one 2017 04 0612(4) e0175052 doi 10.1371/journal.pone.0175052
Abstract

The aim of this study was to clarify the association of IL-1RN variable number of tandem repeat (VNTR) polymorphism and H. pylori infection. We performed a meta-analysis of studies retrieved by systematic searches of Pubmed, Embase and the Cochrane Library. Data were analyzed with STATA 13.1 using pooled odds ratios (ORs) with 95% confidence intervals (CIs). A total of 18 studies were included in our meta-analysis, and IL-1RN VNTR was found to be significantly associated with H. pylori infection in the comparisons of 22+2L vs. LL (OR = 1.17, 95% CI = 1.02-1.33) and 2 allele vs. L allele (OR = 1.18, 95% CI = 1.00-1.40). Stratified analyses on study designs and ethnicities were also conducted. IL-1RN VNTR was positively correlated with H. pylori infection in Asian subgroup and Hospital-Based subgroup (i.e., study samples obtained from hospital inpatients). In conclusion, our study demonstrated that IL-1RN VNTR polymorphism might increase the risk of H. pylori infection, especially in Asians.

Submit a Comment

Your email address will not be published. Required fields are marked *

17 − six =

[ HIDE/SHOW ]