Previous research had linked population-wide psychosocial or environmental stressors to an increased risk of acute cardiovascular disease (CVD). Researchers sought to look into acute cardiovascular disease (CVD) admissions for a study following the 2020 presidential election. Following the 2020 presidential election, the retrospective cohort study looked at acute CVD hospitalizations. Adult members of Kaiser Permanente Southern California and Kaiser Permanente Northern California, 2 large, integrated health care delivery systems, were eligible to participate. From March to July 2021, statistical analysis was carried out. Following the election, rates of hospitalisation for CVD (666 hospitalizations; rate=760.5 per 100,000 person-years [PY]) were 1.17 times higher (95% CI, 1.05-1.31) among 6,396,830 adults (3,970,077 [62.1%] aged 18 to 54 years; 3,422,479 [53.5%] female; 1,083,128 [16.9%] Asian/Pacific Islander, 2,101,367 [32.9%] Hispanic and 2,641,897 [41.3%] White) compared with the same 5-day period 2 weeks prior (569 hospitalizations; rate=648.0 per 100,000 PY). AMI rates were much higher (RR, 1.42; 95% CI, 1.13-1.79). There was no significant difference for stroke (RR, 1.02; 95% CI, 0.86-1.21) or HF (RR, 1.18; 95% CI, 0.98-1.42). Following the 2020 presidential election, there was a higher incidence of acute CVD hospitalization. There was a need for increased awareness of the increased risk of CVD and ways to decrease risk during major political events.