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Association of vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients.

Association of vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients.
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Cusato J, Boglione L, De Nicolò A, Imbornone R, Cardellino CS, Ghisetti V, Carcieri C, Cariti G, Di Perri G, D'Avolio A,


Cusato J, Boglione L, De Nicolò A, Imbornone R, Cardellino CS, Ghisetti V, Carcieri C, Cariti G, Di Perri G, D'Avolio A, (click to view)

Cusato J, Boglione L, De Nicolò A, Imbornone R, Cardellino CS, Ghisetti V, Carcieri C, Cariti G, Di Perri G, D'Avolio A,

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Pharmacogenomics 2017 04 28() doi 10.2217/pgs-2016-0041

Abstract
AIM
Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon.

METHODS
We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR.

RESULTS
 VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses.

CONCLUSION
Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.

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