Four distinct multimorbidity patterns were associated with asthma exacerbation risk, according to a recent study published in The Journal of Allergy and Clinical Immunology: In Practice. The researchers conducted a retrospective analysis of 849 older adults with asthma. Using Mini Batch K-Means clustering, the study authors categorized patients into clusters with predominantly allergic (27.3%), respiratory (14.4%), cardiometabolic (17.6%), and minimal comorbidity (40.8%) profiles. Cluster 2 (respiratory comorbidities) had significantly higher odds of intensive care unit admission (OR, 2.30), noninvasive ventilation (OR, 2.68), mechanical ventilation (OR, 1.93), and 1-year emergency department revisits for asthma (OR, 3.10). Cluster 3 (cardiometabolic comorbidities) showed the highest risk for 1-year readmission (OR, 2.53) and emergency department revisits related to comorbidities (OR, 1.84). Cluster 4 (minimal comorbidity) had the most favourable outcomes. Logistic regression confirmed that these patterns were independently associated with poor prognosis. The researchers concluded that asthma comorbidities represent distinct risk phenotypes that may serve as treatable traits to reduce exacerbations