For a review, it was determined that specific IgE and skin test findings should not be reported as ‘positive’ or ‘negative’ in clinical practice, but as the amount of IgE and the size of the skin test wheel diameter. These tests were not mutually exclusive, but rather complementary, in the assessment of children with severe asthma, and both should be performed and measured. The measurement of allergen-specific IgG might increase their diagnostic accuracy in children with wheeze in the near future. Asthma was rapidly becoming recognized as a group of disorders with similar/same symptoms, rather than a singular disease. The separate disease entities (endotypes) may have identical visible traits (phenotypes), but they develop through diverse pathophysiological pathways. In children with asthma, observable phenotypic traits (for example, sputum inflammatory phenotypes)were not constant. The identification of novel, latent asthma endotypes necessitated the incorporation of a temporal component to account for phenotypic instability and longitudinal alterations. Not only did the term “atopy” referred to asthma, but it also referred to a variety of distinct endotypes that differed in their relationship with asthma.

Through the integration of computational thinking and creative mathematical methodologies with biological research, novel endotypes of atopy and asthma that better represent the specific pathophysiological mechanisms driving diverse illnesses in the atopy and asthma syndromes may be described. These new endotypes may be more useful in epidemiological, genetic, and medicinal research.