The diverse diseases that affect people and health systems characterize asthma and COPD. This study focuses on evidence that British and Dutch theories are trying early to understand their etiology. The function of eosinophils, IL-5s and biologics in asthma and COPD is also discussed. Clusters are based on phenotyped and biological indicators that allow deeper knowledge of endotypes among asthma and COPD patients. The role of eosinophils and optimum treatments for each disease may be different from recent research. 

While people with ACOS or overlap may be an exception, general evidence showing asthma and COPD are different processes appears to be additional. The use of anti-IL-5 eosinophils in a well chosen patient with asthma seems to be a promising approach and new research supports COPD usage.