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Astrocytic glycogen metabolism in the healthy and diseased brain.

Astrocytic glycogen metabolism in the healthy and diseased brain.
Author Information (click to view)

Bak LK, Walls AB, Schousboe A, Waagepetersen HS,


Bak LK, Walls AB, Schousboe A, Waagepetersen HS, (click to view)

Bak LK, Walls AB, Schousboe A, Waagepetersen HS,

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The Journal of biological chemistry 2018 03 23() pii jbc.R117.803239
Abstract

The brain contains a fairly low amount of glycogen, mostly located in astrocytes, a fact that has prompted the suggestion that glycogen does not have a significant physiological role in the brain. However, glycogen metabolism in astrocytes is essential for several key physiological processes and is adversely affected in disease. For instance, diminished ability to break down glycogen impinges on learning, and epilepsy, Alzheimer’s disease, and type 2 diabetes are all associated with abnormal astrocyte glycogen metabolism. Glycogen metabolism supports astrocytic Kand neurotransmitter glutamate uptake and subsequent glutamine synthesis – three fundamental steps in excitatory signaling at most brain synapses. Thus, there is abundant evidence for a key role of glycogen in brain function. Here, we summarize the physiological brain functions that depend on glycogen, discuss glycogen metabolism in disease, and investigate how glycogen breakdown is regulated at the cellular and molecular levels.

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