Other immune-mediated diseases are frequently associated with both atopic dermatitis and celiac disease. The goal of this study was to look at the possible link between atopic dermatitis and celiac disease in a large community-based sample. The study employed a cross-sectional observational design. In 2002–17, individuals registered in a major health management organisation who were diagnosed with atopic dermatitis by a dermatologist were asked to provide demographic and clinical information. The presence of celiac disease/celiac disease-related morbidities was documented in the entire group, adults, and adults with moderate-to-severe atopic dermatitis. The results were compared to a matched control group that did not have atopic dermatitis. The research group included 116,816 patients, 45,157 of whom were adults, and 1909 of them had moderate-to-severe atopic dermatitis. The prevalence rate of celiac disease in the overall group was 0.6 percent vs. 0.4 percent; in adults, 0.6 percent vs. 0.3 percent; and in adults with moderate-to-severe atopic dermatitis, 0.8 percent vs. 0.3 percent. Atopic dermatitis was linked with a significantly greater frequency of celiac disease in the whole study population and each subgroup, according to multivariate analysis.

There was a substantial link between atopic dermatitis and celiac disease. This organisation highlights the need for early detection of gastrointestinal morbidities in people with atopic dermatitis in order to avoid long-term consequences.