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Author: Mukuntha Subburayan

KHN’s ‘What the Health?’: A Health-Heavy State of the Union

President Joe Biden spent a large portion of his first State of the Union address talking about foreign affairs, but he also spent time on an array of health topics, including mental health, nursing home regulation, and toxic burn pits. Also this week, the administration unveiled a strategy to address the covid pandemic going forward. Alice Miranda Ollstein of Politico, Amy Goldstein of The Washington Post, and Sarah Karlin-Smith of the Pink Sheet join KHN’s Julie Rovner to discuss these issues and more. Plus, for extra credit, the panelists recommend their favorite health policy stories of the week they think you should read, too.

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Open-label placebo effective therapy for children with functional abdominal pain or irritable bowel syndrome

1. In a crossover randomized controlled trial of 30 children with functional abdominal pain or irritable bowel syndrome, patient-reported pain scores decreased slightly but significantly with an open-label placebo. 2. Patients’ use of rescue pain medication was also significantly lower during use of the placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: Disorders of gut-brain […]

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Allopurinol Does Not Increase Mortality in Patients With Gout & Chronic Kidney Disease

1. In patients with gout and chronic kidney disease, the initiation of allopurinol was not associated with increased mortality. 2. In patients with gout and chronic kidney disease, dose escalation of allopurinol nor achieving target serum urate levels was associated with increased mortality. Evidence Rating Level: 2 (Good) Study Rundown: Serum urate (SU) lowering medications […]

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Molnupiravir does not improve clinical outcomes in patients hospitalized with COVID-19

1. Patients hospitalized with COVID-19 receiving at least one dose of molnupiravir did not show reduced mortality compared to patients receiving placebo treatment. 2. Molnupiravir was not associated with any dose-limiting side effects. Evidence Rating Level: 1 (Excellent) Study Rundown: Molnupiravir is a small molecule that interferes with the viral genome replication process in RNA […]

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Neoadjuvant chemoradiotherapy demonstrates a long-term survival benefit in pancreatic cancer patients when compared to upfront surgery

1. The use of a neoadjuvant gemcitabine-based chemoradiotherapy before surgery and adjuvant gemcitabine increased the overall survival rate when compared to upfront surgery and adjuvant gemcitabine. 2. Patients in the neoadjuvant chemoradiotherapy groups had more R0 resections than patients receiving upfront surgery and adjuvant gemcitabine. Evidence Rating Level: 1 (Excellent) Study Rundown: Past randomized control […]

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Betibeglogene autotemcel gene therapy effective for β-thalassemia

1. Betibeglogene autotemcel (beti-cel) gene therapy resulted in sustained hemoglobin A with a T87Q amino acid substitution (HbAT87Q) in non-β0/β0 genotype patients. 2. The gene therapy resulted in a total hemoglobin level sufficient for transfusion independence in these patients. Evidence Rating Level: 1 (Excellent) Study Rundown: β-thalassemia is caused by β-globin gene mutations, leading to […]

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