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Autoimmune hepatitis: from current knowledge and clinical practice to future research agenda.

Autoimmune hepatitis: from current knowledge and clinical practice to future research agenda.
Author Information (click to view)

Sebode M, Hartl J, Vergani D, Lohse AW, ,


Sebode M, Hartl J, Vergani D, Lohse AW, , (click to view)

Sebode M, Hartl J, Vergani D, Lohse AW, ,

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Liver international : official journal of the International Association for the Study of the Liver 2017 04 22() doi 10.1111/liv.13458
Abstract

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease. Unknown triggers lead to a mainly T cell-mediated immune response targeting the liver, the main auto-antigen of which has not been identified yet. The diagnosis of AIH is based on the elevation of immunoglobulin G / hypergammaglobulinemia, detection of characteristic autoantibodies as well as a typical pattern on liver histology. Exclusion of other causes of hepatitis and response to immunosuppressive treatment support the diagnosis of AIH. The mainstay of AIH treatment has, from its first description to the current time, consisted of predniso(lo)ne to induce remission, in combination with azathioprine, which is used to maintain it. Nonetheless, side effects and non-response with ongoing inflammation despite standard therapy demand treatment alternatives. Only through a better understanding of the pathogenesis of AIH can a more selective and effective treatment be offered to patients in the future. Until this goal is reached, improvement of diagnostic approaches and optimization of current therapy rank highest on the research agenda for AIH. This article is protected by copyright. All rights reserved.

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