Introducing baked milk immediately following the diagnosis of a cow’s milk allergy was safe and effective in infants younger than 1, according to findings published in Allergy: European Journal of Allergy and Clinical Immunology. Yvonne M. d’Art, MB, MSc, and colleagues enrolled infants with suspected IgE-mediated cow’s milk allergy to study the intervention, a single dose of fresh cow’s milk (using a validated dose that would elicit reactions in 5% of subjects with cow’s milk allergy, the ED05), compared with routine care. Both groups implemented graded exposure to cow’s milk at home. The researchers followed 57 patients for 6 months, at which point 27/37 infants (73%) in the intervention group reached step 6 or higher on the milk ladder compared with 10/20 infants (50%) in the control group. At 6 months, 11/37 (30%) infants in the intervention group had reached step 12 (drinking unheated cow’s milk) compared with 2/20 (10%) infants in the control group. Twelve months after randomization, 24/37 infants (65%) in the intervention group were at step 12, compared with 7/20 infants (35%) in the control group.
