There is a bidirectional association between nonalcoholic fatty liver disease (NAFLD) and psoriasis, especially for patients younger than 40, according to a study published in Frontiers in Immunology. Shuo Yan Gau and colleagues examined the relationship among patients with new-onset NAFLD and psoriasis in two cohorts; propensity scorematched controls with no NAFLD or psoriasis were included for each comparison cohort. The investigators observed a significantly increased risk for developing psoriasis among patients with new-onset NAFLD (HR, 1.07), while for younger patients with NAFLD, the risk was increased 1.3-fold. For new-onset psoriasis, the risk for developing NAFLD in the future was increased 1.28-fold compared with those without psoriasis; the risk was higher for patients in psoriasis subgroups younger than age 40 versus those in older subgroups (adjusted HR, 1.55).
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