This study aimed to analyze, in vitro, the potential of pure Ti, A, Nb, and Zr to avoid the microorganisms S.a and P.a. Furthermore, our objective was to evaluate if the basic elements of Ti-35Nb-7Zr alloy have any influence on bone marrow stromal cells, the source of stem cells, and observe if these metals have properties to induce cell differentiation into osteoblasts.

All samples presented cell proliferation, growth, and spreading. All groups presented cell viability above 70%, but the A showed better results, with statistical differences from Nb and Zr samples. Zr expressed higher ALP activity and was statistically different from the other groups. In contrast, no statistical difference was observed between the samples as regards mineralization nodules. Lower biofilm formation of S.a and P.a. was observed on the Nb samples, with statistical differences from the other samples.

The study concluded that the basic elements present in the alloy have osteoinductive characteristics, and Zr has a good influence on bone marrow stromal cell differentiation. We also believe that Nb has the best potential for reducing the formation of microbial biofilms.

Reference: https://journalimplantdent.springeropen.com/articles/10.1186/s40729-020-00261-3