The present systematic review and meta-analysis try to establish the cerebrospinal fluid (CSF) and serum/plasma levels of iron and iron-related proteins (ferritin, transferrin, lactoferrin, haptoglobin, and hepcidine) levels, and the urine levels of iron, in patients with Parkinson’s disease (PD).
Four Databases (PubMed, EMBASE, MedLine, and Web of Science – Core Collection) were reviewed from 1966 to October 5, 2020. References of interest for the topic were identified. The meta-analysis of eligible studies, that followed the PRISMA and MOOSE guidelines, was performed with the R software package meta.
PD patients showed, when compared with age-and sex-matched controls, a non-significant trend towards higher CSF iron levels, and marginally significantly lower serum/plasma iron levels. CSF and serum/plasma ferritin and transferrin, and serum/plasma lactoferrin and haptoglobin concentrations did not differ significantly between PD patients and controls.
The findings of these study suggest an association between decreased serum/plasma iron levels and, possibly of higher CSF iron levels, with the risk for PD.

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