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Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: The Johnston County Osteoarthritis Project.

Biomarkers reflect differences in osteoarthritis phenotypes of the lumbar spine: The Johnston County Osteoarthritis Project.
Author Information (click to view)

Goode AP, Nelson AE, Kraus VB, Renner JB, Jordan JM,


Goode AP, Nelson AE, Kraus VB, Renner JB, Jordan JM, (click to view)

Goode AP, Nelson AE, Kraus VB, Renner JB, Jordan JM,

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Osteoarthritis and cartilage 2017 07 12() pii S1063-4584(17)31086-5
Abstract
OBJECTIVE
To determine differences in biomarker levels between radiographic phenotypes of facet joint osteoarthritis (FOA) only, spine OA only ((disc space narrowing (DSN) and vertebral osteophytes (OST)) or the combination of FOA and spine OA.

DESIGN
A cross-sectional analysis of data from 555 participants in the Johnston County Osteoarthritis Project was performed. Lumbar spine levels were graded by severity (OST and DSN) and presence (FOA) of degeneration. Biomarkers included hyaluronan (HA) and type II collagen (CTX-II). Adjusted risk ratios (aRRR) were estimated using multinomial regression, with adjustment for age, race, sex, body mass index (BMI), and radiographic OA (knee, hip, hand). Interactions were tested between sex, race and low back symptoms.

RESULTS
FOA only was present in 22.4%, 14.5% had spine OA only, and 34.6% had the combination of FOA and spine OA. Compared to the reference group of neither FOA or spine OA, a one unit higher ln HA level was associated with 31% higher relative risk ratio (RRR=1.31 ((95% 1.03, 1.67)) of having FOA only, while, a one unit higher ln uCTX-II level was associated with 84% higher relative risk ratio (RRR=1.84 ((95% CI 1.19, 2.84)) of having spine OA only. No significant interactions were identified.

CONCLUSION
Interestingly, OA affecting the synovial facet joint was associated with a marker of inflammation (HA). Spine OA, affecting intervertebral discs that contain collagen type II, was associated with a marker reflecting collagen type II degradation (CTX-II). These findings suggest that biomarkers may reflect the different pathophysiologic processes of lumbar spine OA phenotypes.

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