Patients with HF receiving blended care for both HF and depression reported significantly better mental health-related quality of life, or QOL, and mood at 12 months versus those receiving usual care, according to a study published in JAMA Internal Medicine. At 12 months, among 756 participants with HF with reduced left ventricular ejection fraction (<45%), blended care participants reported improvement on the Mental Component Summary of the 12-item Short Form Health Survey versus usual care, but similar scores to the collaborative care for HF only group. Significant improvements in mood for blended care participants were seen versus usual care and collaborative care for the HF-only groups. However, physical function, HF pharmacotherapy use, rehospitalization, and mortality were similar by both baseline depression and randomization status.