THURSDAY, Jan. 12, 2017 (HealthDay News) — Beta-blockers are associated with significantly reduced mortality, but not hospitalizations, in patients with heart failure and reduced ejection fraction (HFrEF) and atrial fibrillation (AF), according to a study published online Jan. 11 in JACC: Heart Failure.
Julia Cadrin-Tourigny, M.D., from the Université de Montréal, and colleagues examined the impact of beta-blockers on mortality and hospitalizations in patients with AF and HFrEF in the AF-CHF trial. Among 1,376 subjects randomized in the trial, the authors propensity-matched those without beta-blockers at baseline to a maximum of two exposed patients.
The researchers found that β-blockers correlated with significantly lower all-cause mortality (hazard ratio [HR], 0.721) but not hospitalizations (HR, 0.886) during a median follow-up of 37 months. In sensitivity analyses that modeled beta-blockers as a time-dependent variable the results were similar (HR for all-cause mortality, 0.668; HR for hospitalizations, 0.814). With respect to mortality and hospitalizations, there were no significant interactions for beta-blockers and pattern or burden of AF.
“These results support current evidence-based recommendations for β-blockers in patients with HFrEF, whether or not they have associated AF,” the authors write.
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