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Blood cytokine concentrations of pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma patients.

Blood cytokine concentrations of pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma patients.
Author Information (click to view)

Knörr F, Damm-Welk C, Ruf S, Singh VK, Zimmermann M, Reiter A, Woessmann W,


Knörr F, Damm-Welk C, Ruf S, Singh VK, Zimmermann M, Reiter A, Woessmann W, (click to view)

Knörr F, Damm-Welk C, Ruf S, Singh VK, Zimmermann M, Reiter A, Woessmann W,

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Haematologica 2017 12 14() pii haematol.2017.177972
Abstract

Patients with anaplastic lymphoma kinase -positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, an unspecific immune stimulation by the tumor or differences in the strength of the patient’s anti-lymphoma immunity. We systematically correlated pre-treatment concentrations of 25 cytokines with clinical and biological characteristics in a well characterized cohort of 119 uniformly treated pediatric anaplastic large cell lymphoma patients. 15 anaplastic large cell lymphoma patients in remission and 11 low-stage B-cell lymphoma patients served as controls. Concentrations of IL-9, IL-10, IL-17a, HGF, sIL-2R, and sCD30 were significantly elevated in initial sera of patients as compared to both control groups, indicating an anaplastic large cell lymphoma-type cytokine signature. The levels of IL-6, IFN-ɣ, IP-10, and sIL-2R correlated with the stage, initial general condition, minimal disseminated disease, ALK-antibody titers, and the risk of relapse among ALK-positive anaplastic large cell lymphoma patients. Only IL-6 showed an independent prognostic value in multivariate analyses. Pre-treatment cytokine profiles in anaplastic large cell lymphoma patients reflect both a tumor-signature as well as tumor burden and differences in the strength of the patient’s immune response.

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