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Blood pressure variability is independent of systolic pressure in adolescent and young adult patients undergoing hemodialysis.

Blood pressure variability is independent of systolic pressure in adolescent and young adult patients undergoing hemodialysis.
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Da J, Zhang Z, Shen Y, Li Q, Hu Y, Zha Y,


Da J, Zhang Z, Shen Y, Li Q, Hu Y, Zha Y, (click to view)

Da J, Zhang Z, Shen Y, Li Q, Hu Y, Zha Y,

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Pediatric research 2017 11 22() doi 10.1038/pr.2017.293
Abstract
OBJECTIVE
Pre-dialysis blood pressure variability (BPV) in adolescent and young-adult maintenance hemodialysis (MHD) patients remains unknown. This study aimed to show the degree of 44-hour BPV and to explore its related risk factors in adolescent and young-adult MHD patients.

METHOD
One hundred and fifty-three hemodialysis patients aged from 14 to 29 were selected from 11 medical facilities in Guizhou, China. Variability independent of mean BP (VIM) obtained by 44-hour ambulatory BP monitoring was used to calculate BPV. Baseline characteristics, physical measurement and laboratory parameters were compared between different groups categorized by quartiles of VIM of systolic BP (VIMSBP).

RESULT
VIMSBP levels were found to be positively related to interdialytic weigh growth rate (IDWG), serum phosphorus and serum iPTH (Spearman correlation coefficients 0.474, 0.229 and 0.437, respectively; P<0.05 for all), negatively related with hemoglobin and albumin (-0.317, P<0.001 and -0.166, P=0.04, respectively) in all adolescent and young-adult MHD patients. In multiple linear regression analysis, IDWG, Hemoglobin, Serum phosphorus and Serum iPTH had an independent association with VIMSBP. CONCLUSION
Our analysis revealed an independent association of BPV with IDWG, hemoglobin, serum phosphorus and serum iPTH among adolescent and young-adult patients undergoing dialysis. This observation warrants further study.Pediatric Research accepted article preview online, 22 November 2017. doi:10.1038/pr.2017.293.

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