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Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons.

Body mass index, inflammatory biomarkers and neurocognitive impairment in HIV-infected persons.
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Okafor CN, Kelso NE, Bryant V, Burrell LE, Míguez MJ, Gongvatana A, Tashima KT, de la Monte S, Cook RL, Cohen RA,


Okafor CN, Kelso NE, Bryant V, Burrell LE, Míguez MJ, Gongvatana A, Tashima KT, de la Monte S, Cook RL, Cohen RA, (click to view)

Okafor CN, Kelso NE, Bryant V, Burrell LE, Míguez MJ, Gongvatana A, Tashima KT, de la Monte S, Cook RL, Cohen RA,

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Psychology, health & medicine 2016 06 2022(3) 289-302 doi 10.1080/13548506.2016.1199887

Abstract

To determine the relationships among body mass index (BMI), and HIV-associated neurocognitive impairment and the potential mediating effects of inflammatory cytokines. Among the HIV-infected individuals (N = 90) included in this study, obesity was associated with slower processing speed (β = -.229, standard error (SE) = 2.15, p = .033), compared to participants with a normal BMI, after controlling for psychosocial and HIV clinical factors. Serum concentrations of the interleukin-16 (IL-16) cytokine were significantly associated with slowed processing speed (β = -.235, SE = 1.62, p = .033) but did not mediate the relationship between obesity and processing speed These findings suggest that obesity may contribute to cognitive processing speed deficits in HIV-infected adults. Elevated concentrations of IL-16 are also associated with slowing, though the results suggest that obesity and IL-16 may exert independent effects.

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