Advertisement

 

 

Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression.

Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression.
Author Information (click to view)

Brun J, Berthou F, Trajkovski M, Maechler P, Foti M, Bonnet N,


Brun J, Berthou F, Trajkovski M, Maechler P, Foti M, Bonnet N, (click to view)

Brun J, Berthou F, Trajkovski M, Maechler P, Foti M, Bonnet N,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Diabetes 2017 07 07() pii db170116
Abstract

Peroxisome proliferator-activated receptor gamma (PPARγ) is a master regulator of energy metabolism. In bone it is known to regulate osteoblast differentiation and osteoclast activity. Whether PPARγ expression in bone cells, particularly osteocytes, regulates energy metabolism remains unknown. Here we show that mature osteoblast/osteocyte-specific ablation of PPARγ in mice (Ocy-PPARγ(-/-) ) alters body composition with age, namely less fat and more lean mass and enhances insulin sensitivity and energy expenditure compared to wildtype. In addition, Ocy-PPARγ(-/-) mice exhibit higher bone density, structure and strength by uncoupling bone formation from resorption. When challenged with a high fat diet, Ocy-PPARγ(-/-) mice retain their glycemic control, with increased browning of the adipose tissue, decreased gluconeogenesis and less hepatic steatosis. Moreover, these metabolic effects, particularly an increase in fatty acid oxidation, cannot be explained by decarboxylated osteocalcin changes, suggesting existence of other osteokines which are under the control of PPARγ. We further identify bone morphogenetic protein 7 as one of them. Hence osteocytes coregulate bone and glucose homeostasis through a PPARγ regulatory pathway and its inhibition could be clinically relevant for the prevention of glucose metabolic disorders.

Submit a Comment

Your email address will not be published. Required fields are marked *

seventeen − 1 =

[ HIDE/SHOW ]