For a study, researchers sought to understand that limiting dismalness and enteral independence is the essential objective in the clinical administration of patients with short bowel syndrome (SBS). It was frequently hard to accomplish in light of huge malabsorption. Until this point, there were restricted treatments that further developed retention in patients with SBS. The effect of pancreatic protein substitution treatment on enteral retention had not been concentrated on in this populace and was the essential point of this review. It was an interventional concentrate on 11 subjects (6 pediatric subjects aged 4.0-17.9 years, 5 grown-up subjects 18-75 years) that looked at enteral retention in each subject when pancreatic catalyst prescription (Creon). Coefficient of fat ingestion (CFA) and coefficient of nitrogen retention (CNA) was individually utilized as enteral retention of fat and protein markers. There was no measurably critical mean change in CFA and CNA when pancreatic catalyst prescription treatment. About 6 subjects exhibited an expansion in CFA, and 8 subjects showed an expansion in CNA after using pancreatic catalyst prescription treatment. The companion had no genuinely critical improvement in enteral fat and protein retention. However, a few subjects showed an improvement. These outcomes propose that a few patients with SBS might profit from treatment with pancreatic catalysts. Further examinations were expected to assess the impact of pancreatic protein treatment on enteral retention in subjects with SBS and to describe factors that might foresee a positive reaction.