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Brain Cells that Control Appetite Identified for First Time

Brain Cells that Control Appetite Identified for First Time
Author Information (click to view)

University of Warwick


University of Warwick (click to view)

University of Warwick

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Dieting could be revolutionised, thanks to the ground-breaking discovery by the University of Warwick of the key brain cells which control our appetite.

Professor Nicholas Dale in the School of Life Sciences has identified for the first time that tanycytes — cells found in part of the brain that controls energy levels — detect nutrients in food and tell the brain directly about the food we have eaten.

According to the new research, tanycytes in the brain respond to amino acids found in foods, via the same receptors that sense the flavour of amino acids (“umami” taste), which are found in the taste buds of the tongue.

Two amino acids that react most with tanycytes — and therefore are likely to make you feel fuller — are arginine and lysine.

These amino acids are found in high concentration in foods such as pork shoulder, beef sirloin steak, chicken, mackerel, plums, apricots, avocadoes, lentils and almonds — so eating those foods will activate the tanycytes and make you feel less hungry quicker.

The researchers made their discovery by adding concentrated amounts of arginine and lysine into brain cells, which were made fluorescent so that any microscopic reactions would be visible. They observed that within thirty seconds, the tanycytes detected and responded to the amino acids, releasing information to the part of the brain that controls appetite and body weight.

They found that signals from amino acids are directly detected by the umami taste receptors by removing or blocking these receptors and observing that the amino acids no longer reacted with tanycytes.

Click here to read the full press release.

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