To investigate the behavioral and neuronal responses of patients with migraine to a visual stimulation of self-motion through a virtual roller coaster ride, in comparison to controls.
Twenty consecutive migraine patients from a university-based hospital headache clinic and 20 controls were included. Participants underwent an experiment where a visually displayed self-motion paradigm was presented based on customized roller coaster videos during fMRI. Within each video, blocks of motion stimulation were interleaved with low speed upward motion in a random order. In the scanning intervals and after the experiment, participants rated their perceived level of vestibular symptoms and motion sickness during the videos. We hypothesized that migraine patients will perceive more motion sickness and that this correlates with a different central processing and brain responses.
Compared to controls, migraine patients reported more dizziness (65% 30% p= 0.03) and motion sickness [SSQ score 47.3 (95%CI 37.1, 57.5) 24.3 (95%CI 18.2, 30.4)] as well as longer symptom duration [01:19 min (95%CI 00:51, 01:48) 00:27 min (95%CI 00:03, 00:51)] and intensity [VAS 0-100, 22.0 (95%CI 14.8, 29.2) 9.9 (95%CI 4.9, 14.7)] during the virtual roller coaster ride. Neuronal activity in migraine patients were more pronounced in clusters within the superior [Contrast estimate 3.005 (90%CI 1.817, 4.194)] and inferior occipital gyrus [Contrast estimate 1.759 (90%CI 1.062, 2.456)], pontine nuclei [Contrast estimate 0.665 (90%CI 0.383, 0.946)] and within the cerebellar lobules V/VI [Contrast estimate 0.672 (90%CI 0.380, 0.964)], while decreased activity was seen in the cerebellar lobule VIIb [Contrast estimate 0.787 (90%CI 0.444, 1.130)] and in the middle frontal gyrus [Contrast estimate 0.962 (90%CI 0.557, 1.367)]. These activations correlated with migraine disability (r= -0.46, p= 0.04) and motion sickness scores (r= 0.32, p= 0.04). We further found enhanced connectivity between the pontine nuclei, cerebellar areas V/VI, interior and superior occipital gyrus with numerous cortical areas in migraine patients but not in controls.
Migraine is related to abnormal modulation of visual motion stimuli within superior and inferior occipital gyrus, middle frontal gyrus, pontine nuclei, cerebellar lobules V, VI and VIIb. These abnormalities relate to migraine disability and motion sickness susceptibility.

© 2021 American Academy of Neurology.

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