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Burden and Epidemiology of Influenza- and Respiratory Syncytial Virus-Associated Severe Acute Respiratory Illness Hospitalization in Madagascar, 2011-2016.

Burden and Epidemiology of Influenza- and Respiratory Syncytial Virus-Associated Severe Acute Respiratory Illness Hospitalization in Madagascar, 2011-2016.
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Rabarison JH, Tempia S, Harimanana A, Guillebaud J, Razanajatovo NH, Ratsitorahina M, Heraud JM,


Rabarison JH, Tempia S, Harimanana A, Guillebaud J, Razanajatovo NH, Ratsitorahina M, Heraud JM, (click to view)

Rabarison JH, Tempia S, Harimanana A, Guillebaud J, Razanajatovo NH, Ratsitorahina M, Heraud JM,

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Influenza and other respiratory viruses 2018 04 06() doi 10.1111/irv.12557
Abstract
BACKGROUND
Influenza and respiratory syncytial virus (RSV) infections are responsible for substantial global morbidity and mortality in young children and elderly individuals. Estimates of the burden of influenza- and RSV-associated hospitalization are limited in Africa.

METHODS
We conducted hospital-based surveillance for laboratory-confirmed influenza- and RSV-associated severe acute respiratory illness (SARI) at one hospital and a retrospective review of SARI hospitalizations in five hospitals situated in Antananarivo during 2011-2016. We estimated age-specific rates (per 100,000 population) of influenza- and RSV-associated SARI hospitalizations for the Antananarivo region and then extrapolated these rates to the national level.

RESULTS
Overall the mean annual national number of influenza-associated SARI hospitalizations for all age groups was 6,609 (rate: 30.0); 4,468 (rate: 127.6) and 2,141 (rate: 11.6) among individuals aged <5 and ≥5 was respectively. For these same age groups, the mean annual number of RSV-associated SARI hospitalizations was 11,768 (rate: 53.4), 11,299 (rate: 322.7) and 469 (rate: 2.5), respectively. CONCLUSION
The burden of influenza- and RSV-associated SARI hospitalization was high among children aged <5 years. These first estimates for Madagascar will enable government to make informed evidence-based decisions when allocating scarce resources and planning intervention strategies to limit the impact and spread of these viruses. This article is protected by copyright. All rights reserved.

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