Bisphenol A (BPA), a widespread industrial substance is recognized as endocrine disrupting chemical and therefore could be associated with polycystic ovary syndrome (PCOS) related metabolic disturbances. Patients In this study 29 women of reproductive age with diagnosed PCOS were enrolled.
BPA in urine samples was analyzed by gas chromatography-mass spectrometry.
BPA was detected in urines of 48.28% participants. The waist-to-height ratio (WtHR) was statistically significant higher in PCOS BPA+ in comparison to PCOS BPA- women (p=0.046). PCOS BPA+ women had 6.88 times (95%Cl 1.3481-35.0600, z=2.319, p=0.020) higher risk for waist circumference above 80 cm and 4.95 odds (95%Cl 1.0169-24.096, z=1.981, p=0.048) to have WtHR over 0.5 when compared to PCOS BPA-. Statistically significant positive association between BPA urine concentrations and insulin serum levels (p=0.038) was obtained. BPA urine values were associated with elevated HOMA-IR values and reduced HDL levels with moderate significance (p=0.079 and p=0.061, respectively). Also, there was 3.75 times (95%Cl 0.7936-17.7203, z=1.668, p=0.095) higher risk for PCOS BPA+ women to have testosterone levels above reference values.
The obtained results suggested that the BPA exposition in PCOS women was followed by increased metabolic risk through promotion of obesity, especially the visceral type, hyperinsulinemia, insulin resistance, dyslipidemia and elevated androgen levels.
Copyright © 2020. Published by Elsevier B.V.