Mycoses 2017 09 05() doi 10.1111/myc.12696
Invasive Candida infection is the fourth most common bloodstream infection. Blood cultures are the current gold standard diagnostic method, however false negatives remain a clinical challenge. We developed a new technique measuring Candida reactive T cells as diagnostic read-out for invasive Candida infection. In a pilot study, we followed the treatment course of a patient with an invasive Candida infection of the lumbar vertebral spine. We present the case of the 56 year old patient with HIV-associated Burkitt lymphoma who developed septic shock during chemotherapy induced neutropenia. For the first time, we provide flow cytometry based diagnostics with Candida reactive T cells for invasive candidiasis with comprehensive MRI imaging. The Candida reactive T cell assay has potential to complement current diagnostic assays for invasive Candida infection and thus to support targeted treatment. This article is protected by copyright. All rights reserved.