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Candida reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine.

Candida reactive T cells for the diagnosis of invasive Candida infection of the lumbar vertebral spine.
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Koehler FC, Cornely OA, Wisplinghoff H, Chang DH, Richter A, Koehler P,


Koehler FC, Cornely OA, Wisplinghoff H, Chang DH, Richter A, Koehler P, (click to view)

Koehler FC, Cornely OA, Wisplinghoff H, Chang DH, Richter A, Koehler P,

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Mycoses 2017 09 05() doi 10.1111/myc.12696

Abstract

Invasive Candida infection is the fourth most common bloodstream infection. Blood cultures are the current gold standard diagnostic method, however false negatives remain a clinical challenge. We developed a new technique measuring Candida reactive T cells as diagnostic read-out for invasive Candida infection. In a pilot study, we followed the treatment course of a patient with an invasive Candida infection of the lumbar vertebral spine. We present the case of the 56 year old patient with HIV-associated Burkitt lymphoma who developed septic shock during chemotherapy induced neutropenia. For the first time, we provide flow cytometry based diagnostics with Candida reactive T cells for invasive candidiasis with comprehensive MRI imaging. The Candida reactive T cell assay has potential to complement current diagnostic assays for invasive Candida infection and thus to support targeted treatment. This article is protected by copyright. All rights reserved.

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