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Jun 8, 2020
Minimal clinically important difference (MCID) can be defined as the smallest change or difference in an outcome measure that is perceived as beneficial and would lead to a change in the patient’s medical management.The...
Read MoreJun 8, 2020
Parkin (Park2), an E3 ubiquitin ligase, is critical to maintain mitochondrial function by regulating mitochondrial biogenesis and degradation (mitophagy), but recent evidence suggests the involvement of Parkin in promoting...
Read MoreJun 4, 2020
Allergic asthma is one of the most common chronic diseases of the airways, however it still remains underdiagnosed and hence undertreated. Therefore, an allergic asthma rat model would be useful to be applied in future...
Read MoreJun 4, 2020
Psychological stress shifts the immune system toward the production of T-helper (Th)-2-mediated cytokines and eosinophilia, increases the risks for both asthma and depression, and can precipitate asthma exacerbations....
Read MoreJun 4, 2020
Asthma prevalence decreases post-puberty in males. Testosterone inhibits airway smooth muscle contraction and attenuates type 2 inflammation.To investigate the relationship between serum testosterone and current asthma...
Read MoreJun 1, 2020
Anti-IgE (omalizumab) has been used for the treatment of moderate-to-severe asthma that is not controlled by inhaled steroids. Despite its success, it does not always provide patients with significant clinical benefits.To...
Read MoreJun 1, 2020
Glucocorticoids (GCs) are the treatment of choice for chronic inflammatory diseases such as asthma. Despite proven effective anti-inflammatory and immunosuppressive effects, long-term and/or systemic use of GCs can potentially...
Read MoreJun 1, 2020
Airway remodelling is a cardinal feature of asthma in which airways undergo structural changes – in particular, increased airway smooth muscle mass and total airway wall area. Remodelling has long been thought to have...
Read MoreMay 28, 2020
The mite alimentary canal contains plenty of microbiota. It is accepted that some of the microbial products function as adjuvants to speed up immune responses.We identified five bacterial proteins from dust mite, and...
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