Allergy & Immunology General | Physician's Weekly
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Allergy & Immunology General

Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT) in adults 56 years of age and older

Jul 19, 2021

MenACYW-TT is a quadrivalent meningococcal conjugate vaccine under research for the prevention of invasive meningococcal disease (IMD) caused by serogroups A, C, W, and Y in people aged 6 weeks and ab...

Immunogenicity and safety of a booster dose of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT)

Jul 19, 2021

The Phase III experiment looked at the quadrivalent meningococcal tetanus toxoid-conjugate vaccination as a booster. Individuals aged 15 years or older who have been immunised with a quadrivalent meni...

Phenotypes, endotypes and biomarkers in anaphylaxis: current insights

Jul 19, 2021

The goal of this study is to define anaphylactic endotypes by describing distinct clinical presentations of anaphylaxis (phenotypes) in connection to the underlying processes and possible biomarkers. ...

Globalization and anaphylaxis

Jul 19, 2021

Understanding the influence of globalisation on anaphylaxis management and identifying viable ways to enhance patient care and prevention. Anaphylaxis developments have constantly followed these globa...

Biological treatments for severe asthma: where do we stand?

Jul 19, 2021

Disease control is not accomplished in individuals with severe asthma, resulting in long-term morbidity and increased risk of exacerbations. The introduction of biologics has opened up new avenues of ...

Allergen immunotherapy as add-on to biologic agents

Jul 19, 2021

This study attempted to summarise several of the most current pieces of evidence concerning clinical trials involving biologic medicines [i.e. omalizumab (OMA)] and were linked to allergen-specific im...

Role of allergen-specific T-follicular helper cells in immunotherapy

Jul 19, 2021

The identification of new T-cell subsets, such as follicular helper T (Tfh) cells, has increased our understanding of the complex immunological networks involved in allergic disorders. This paper revi...

Nasal challenges in allergen immunotherapy trials

Jul 19, 2021

The nasal allergen challenge (NAC) model can be a useful diagnostic technique for allergic rhinitis. In addition to clinical usage, NACs can be utilised as primary and secondary endpoints in studies a...

Ten-Year Antibody Persistence and Booster Response to MenACWY-TT Vaccine After Primary Vaccination

Jul 19, 2021

This phase 3B, open-label extension study (NCT01962207) compared the long-term persistence of antibodies induced by the quadrivalent meningococcal vaccine conjugated to tetanus toxoid (MenACWY-TT) to ...

Efficacy and safety of a booster dose of the meningococcal A, C, W, Y-tetanus toxoid conjugate vaccine

Jul 19, 2021

A prior phase 3, randomised, multicenter trial demonstrated the immunogenicity of a primary immunisation with the quadrivalent meningococcal vaccine conjugated to tetanus toxoid (MenACWY-TT) or the qu...

The impact of meningococcal conjugate vaccine (MenACWY-TT) on meningococcal carriage

Jul 19, 2021

In 2018, pilgrims in Turkey were given the meningococcal conjugate vaccination for the first time before leaving for Hajj. The purpose of this study was to see if immunisation has any influence on the...

Results from a large post-marketing safety surveillance study in the Republic of Korea with a quadrivalent meningococcal CRM-conjugate vaccine

Jul 19, 2021

MenACWY-CRM, a quadrivalent meningococcal conjugate vaccination, is licenced for use in individuals as young as 2 months old in the Republic of Korea. This single-arm, open-label, observational, multi...

Safety profile of the meningococcal conjugate vaccine (Menafrivac™) in clinical trials and vaccination campaigns

Jul 19, 2021

The purpose of the study was to examine the capacity of AEFI surveillance during immunisation campaigns using the novel conjugate meningitis vaccine (MenAfrivac). A comprehensive review of Menafrivac ...

High risk of mumps infection in children who received one dose of mumps-containing vaccine

Jul 19, 2021

The prevalence of mumps in children aged 2–5 years has been high during the time of vaccination with a single-dose measles-mumps-rubella (MMR) vaccine, which has been available in China since 2008. ...

Secondary antibody deficiency in neurology

Jul 19, 2021

Induction of lymphocyte depletion is becoming more popular as a treatment for central and peripheral neuroinflammatory disorders. However, there is rising awareness of secondary antibody deficit as a ...

Very early onset IBD: novel genetic aetiologies

Jul 19, 2021

To review existing knowledge and new discoveries in the genetic aetiology of extremely early onset inflammatory bowel disease pathogenesis (VEO-IBD) was the purpose of this study. IBD is a chronic gas...

Very early-onset inflammatory bowel disease: an integrated approach

Jul 19, 2021

Immune dysregulation diseases are one of the most rapidly increasing subsets of inborn immune abnormalities. One subgroup is characterised by the most frequent symptom being early-onset inflammatory b...

Advances in site-specific gene editing for primary immune deficiencies

Jul 19, 2021

With substantial advances in the previous decade, conventional gene therapy has proven an effective, curative treatment method for many basic immunological deficiencies. However, there is still a dang...

What is new in HIES? Recent insights from the interface of primary immune deficiency and atopy

Jul 19, 2021

Understanding the pathogenesis of monogenic primary immunodeficiency (PID) with atopic presentation has important implications for therapeutic methods as well as possibly larger polygenic atopic-relat...

Will precision medicine be available for all patients in the near future?

Jul 19, 2021

Evidence-based medicine and recommendations for patient diagnosis and treatment are evolving. General suggestions are shifting toward an individual focus, as technological advancements enable the dete...

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