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Hypertension

Medication Nonadherence in Patients With Hypertension & Diabetes: A Compounding Issue

Oct 15, 2021

According to previous studies, only about one-half of patients with chronic diseases like hypertension and diabetes adhere to at least 80% of their medication regimens. It can be challenging for healt...

Updated reference intervals for urine normetanephrine have no effect on test sensitivity but fewer false positives.

Oct 11, 2021

We previously highlighted the problem of frequent false positives in 24 hour urine normetanephrine(UNM) measurements owing to reference intervals that are inappropriately low for the population being ...

Regulation of meprin metalloproteases in mucosal homeostasis.

Oct 11, 2021

Mucus is covering the entire epithelium of the gastrointestinal tract (GIT), building the interface for the symbiosis between microorganisms and their host. Hence, a disrupted mucosal barrier or alter...

Durable renal response and safety with add-on belimumab in patients with lupus nephritis in real-life setting (BeRLiSS-LN). Results from a large, nationwide, multicentric cohort.

Oct 04, 2021

Belimumab was recently approved for treatment of lupus glomerulonephritis (LN).To evaluate renal response and its predictors in LN patients receiving belimumab in real-life.We considered all patients ...

Soluble guanylate cyclase stimulators and activators: Past, present and future.

Oct 04, 2021

The discovery of the sGC stimulators and sGC activators provided valuable tools to elucidate NO-sGC signalling and opened novel pharmacological opportunities in cardiovascular indications and beyond. ...

Survey on sodium and potassium intake in patients with hypertension in China.

Sep 27, 2021

Sodium and potassium intake in hypertensive patients in China is not clear. The authors aimed to investigate the distribution of sodium and potassium intake in hypertensive patients in China, and to a...

Macroscopic characteristics of the native liver in children with MPV17-related mitochondrial DNA depletion syndrome: an indication for performing liver transplantation?

Sep 20, 2021

Mitochondrial respiratory chain disorders (MRCDs) are rare conditions with various clinical manifestations that depend on the genetic type, with subsequent severity of the liver disease. Clinical pres...

Differential influences of dietary sodium on blood pressure regulation based on race and sex.

Sep 13, 2021

There are clear differences between men and women, and differences among races, in the incidence and prevalence of hypertension. Furthermore, there is extensive inter-individual variability among huma...

Vasodilator use in precapillary pulmonary hypertension with end stage kidney disease: A single center experience.

Sep 13, 2021

Pulmonary hypertension is commonly seen in end stage kidney disease and is most commonly due to elevated left heart pressures. There is limited data about vasodilator use during the management of Grou...

Mineralocorticoid receptors in pulmonary hypertension and right heart failure: From molecular biology to therapeutic targeting.

Sep 06, 2021

Pulmonary hypertension (PH) is a devastating condition characterized by pulmonary vascular remodelling, leading to progressive increase in pulmonary artery pressure and subsequent right ventricular fa...

Propranolol and metoprolol: Two comparable drugs with very different post-mortem toxicological profiles.

Sep 06, 2021

Propranolol is a widely used beta-blocker mainly prescribed for the treatment of hypertension and other cardiac conditions. This medicine is also a frequent finding in drug screens, but little is know...

COVID-19-associated mucormycosis: Case report and systematic review.

Aug 30, 2021

Increasing number of patients with COVID-19-associated mucormycosis have been reported, especially from India recently. We have described a patient with COVID-19-associated mucormycosis and, searched ...

Associations of telomere length at birth with predicted atherosclerotic lesions and cardiovascular disease risk factors in midlife: A 40-year longitudinal study.

Aug 26, 2021

Adult telomere length (TL) is substantially determined by birth TL, but associations of birth TL with cardiovascular disease (CVD) are unknown.We included 144 adult offspring born in 1959-1966 from th...

Genetic predisposition to COVID-19 may increase the risk of hypertension disorders in pregnancy: A two-sample Mendelian randomization study.

Aug 26, 2021

The aim of this study was to apply the Mendelian randomization (MR) design to explore the potential causal association between COVID-19 and the risk of hypertension disorders in pregnancy.Our primary ...

Idiopathic intracranial hypertension: Do we diagnose and manage it appropriately in the light of current data?

Aug 23, 2021

Idiopathic intracranial hypertension (IIH) is an increase of intracranial pressure without a known cause, which usually presented with headache. This study aimed to evaluate the changing diagnosis and...

Left atrial reverse remodeling improves sinus restoration following mitral valve replacement: A case report.

Aug 23, 2021

Mitral stenosis is one of the most common abnormalities in rheumatic heart disease (RHD). These patients often experience atrial fibrillation, due to left atrial dilatation, causing a high risk of thr...

Primary adenocarcinoma of the appendix presenting with fresh bleeding per rectum: A case report.

Aug 19, 2021

Primary adenocarcinoma of appendix is a rarely diagnosed malignancy accounting for less than 6% of appendiceal neoplastic lesions and less than 0.5% of all gastrointestinal malignancies. It is mostly ...

Intensive care unit admission for patients with pulmonary hypertension presenting to U.S. Emergency Departments.

Aug 19, 2021

Pulmonary hypertension (PH) is an important contributor to morbidity and mortality in patients seeking emergency care, resulting in high acuity presentations and resource utilization. The objective wa...

In search of pulmonary hypertension treatments: Effect of 17β-estradiol on PGI pathway in human pulmonary artery.

Aug 19, 2021

Prostacyclin (PGI) is synthetized by PGI synthase (PGIS) and induces vasorelaxation via activation of cyclic AMP (cAMP) generating IP-receptor. Several components of the PGI signaling pathway are redu...

ACUTE LIMB ISCHEMIA AMONG PATIENTS WITH COVID-19 INFECTION.

Aug 16, 2021

SARS-CoV-2 infection has been associated with thrombotic complications such as deep vein thrombosis or stroke. Recently, numerous cases of acute limb ischemia (ALI) have been reported although pooled ...