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Sepsis

Phase I Trial of Definitive Concurrent Chemoradiotherapy and Trametinib for KRAS-Mutated Non-Small Cell Lung Cancer.

Jan 24, 2022

This phase I trial (NCT01912625) evaluated the safety and pharmacokinetics of definitive concurrent chemoradiotherapy (cCRT) and the radiosensitizer trametinib (MEK1/2 inhibitor) for KRAS-mutated nonm...

The effectiveness of branching simulations in improving nurses' knowledge, attitudes, practice, and decision-making related to sepsis assessment and management.

Jan 24, 2022

Nurses have a key role in the early assessment and management of sepsis, which is crucial for optimal quality of care and better patient outcomes. However, sepsis in critical care patients is underrec...

Autotransfusion of vaginally shed blood as a novel therapy in obstetric hemorrhage: A case series.

Jan 10, 2022

To report maternal outcomes in a cohort of women who received autotransfusion of vaginally shed blood and to describe the feasibility of blood collection and cell salvage processing at the time of vag...

CircRNAPTK2 Promotes Cardiomyocyte Apoptosis in Septic Mice by Competitively Binding to miR-29b-3p with BAK1.

Dec 20, 2021

Sepsis is a predominant reason for the growing morbidity and mortality in the world. The role of circular RNAs (CircRNAs) is actively researched in sepsis. In this study, we attempt to find out the ef...

A Deep Learning Model to Predict Sepsis Early

Dec 10, 2021

According to recent estimates, sepsis is attributable to approximately one in three hospital deaths in the United States. “Sepsis is a common and deadly condition that can be difficult to identify i...

A cohort study investigating the occurrence of differences in care provided to men and women in an intensive care unit.

Dec 06, 2021

It has been reported that there are differences in the care given within the intensive care unit (ICU) between men and women. The aim of this study is to investigate if any differences still exist bet...

Results of surgical treatment in chronic anal fissure complicated by abscess or fistula in a retrospective cohort of patients.

Nov 29, 2021

We report the results of the surgical treatment of anal fissures complicated by abscess or fistula and formulate hypotheses about their nature. Among patients operated between 2012 and 2020 for anal f...

Race and sex based disparities in sepsis.

Nov 29, 2021

Studies of sepsis evaluating sex- and race-related disparities in treatment and outcome have been limited by using administrative databases, which may not adequately capture sepsis diagnosis, used lim...

The contribution of neuropilin-1 in the stability of CD4 CD25 regulatory T cells through the TGF-β1/Smads signaling pathway in the presence of lipopolysaccharides.

Nov 15, 2021

This study investigates the synergistic effect of TGF-β1 and Nrp-1 on CD4 CD25 T ' stabilization, and the associated pathways of signal transduction, in vitro models in the presence of LPS.Spleen CD4...

Deficits Found in Identification of Patient Goals Post-Sepsis Hospitalization

Nov 11, 2021

“Growing evidence indicates that survivors of sepsis face multiple health challenges after their initial hospitalization, along with high rates of healthcare utilization and mortality,” explains S...

Clinical characteristics and outcome of 125 polymicrobial bloodstream infections in hematological patients: an 11-year epidemiologic survey.

Nov 08, 2021

Polymicrobial bloodstream infections (pBSI) occurring in hematological patients are still poorly understood, and specific information are very limited.In this epidemiologic survey, we describe clinica...

Application of phosphorus loading models to understand drivers of eutrophication in a complex rural lake-watershed system.

Nov 08, 2021

Several lakes in southwestern Nova Scotia, Canada have experienced reoccurring algal blooms and possess concentrations of phosphorus (P) that are in the eutrophic to hypereutrophic range (>35 μg/L...

Sepsis: Assessing a Biomarker & EMR‐Based Machine Learning Algorithm

Nov 03, 2021

Early antibiotic therapy has been shown to improve outcomes in sepsis, but patients often present with vague symptoms, making it difficult to recognize the condition early. Treatment delays can occur ...

Occurrence and removal of PPCPs from on-site wastewater using nitrogen removing biofilters.

Nov 01, 2021

The presence of pharmaceuticals and personal care products (PPCPs) in the environment is primarily the result of discharge of waste, including from onsite wastewater treatment systems (OWTSs) which ar...

The enteroinsular axis during hospitalization in newborn foals.

Oct 18, 2021

The enteroinsular axis (EIA) is an energy regulatory system that modulates insulin secretion through the release of enteroendocrine factors (incretins). Despite the importance of energy homeostasis in...

Association between platelet count and multiorgan dysfunction and outcomes in patients with sepsis in the pediatric intensive care unit in Saudi Arabia.

Oct 11, 2021

Sepsis is one of the leading causes of morbidity and mortality in the pediatric population worldwide. This study aimed to establish a correlation between platelet count and outcomes of severe sepsis/s...

Fifteen years single-center experience with In Situ Reconstruction for Infected Native Aortic Aneurysms.

Oct 04, 2021

The purpose of this study was to evaluate survival and freedom from reinfection of patients with infected native aortic aneurysms (INAA) managed with in situ revascularization (ISR), either with open ...

Minocycline attenuates oxidative and inflammatory injury in a intestinal perforation induced septic lung injury model via down-regulating lncRNA MALAT1 expression.

Sep 27, 2021

Oxidative stress and inflammatory responses play an important role in acute lung injury (ALI). Although minocycline (MINO) has anti-inflammatory effects and is a promising candidate in treating inflam...

Predicting Long-Term Complications After Sepsis-Associated Acute Kidney Disease

Sep 21, 2021

Sepsis is the most commonly identified risk factor for acute kidney injury (AKI), according to published research. “While we know that sepsis-associated acute kidney injury (SA-AKI) has significant...

Patterns of vascular response immediately after passive mobilization in patients with sepsis: an observational transversal study.

Sep 20, 2021

Sepsis is a serious organ dysfunction leading to endothelial damage in critical patients. Physiologically, there is an augment of vascular diameter in response to increased vascular blood flow and she...