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Sepsis

#VisualAbstract: Intravenous vitamin C increases mortality and organ dysfunction in sepsis patients

Jul 08, 2022

1. In patients with sepsis receiving a vasopressor in the intensive care unit (ICU), intravenous vitamin C was associated with a higher risk of death and persistent organ dysfunction compared to p...

Increased progranulin as an independent predictive biomarker for poor prognosis in sepsis.

May 23, 2022

Recently, many diagnostic biomarkers were reported, but each had its own limitation. However, there is a need for an effective sensitivity and specificity of biomarker in diagnosis and prognosis of se...

A standardized implementation of multicenter quality improvement program of very low birth weight newborns could significantly reduce admission hypothermia and improve outcomes.

May 16, 2022

Admission hypothermia (AH, < 36.5℃) remains a major challenge for global neonatal survival, especially in developing countries. Baseline research shows nearly 89.3% of very low birth weight (...

Innate immune signalling and immunothrombosis: New insights and therapeutic opportunities.

May 16, 2022

Activation of the coagulation cascade is a critical, evolutionarily conserved mechanism that maintains haemostasis by rapidly forming blood clots in response to blood-borne infections and damaged bloo...

Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials.

May 09, 2022

Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that ...

Practical approach to clinical controversies in glycemic control for hospitalized surgical patients.

May 02, 2022

The importance of glycemic management in surgical patient populations stems from an association between hyperglycemia and increased rates of surgical site infections, sepsis, and mortality. Various gu...

Turnbull-Cutait Abdominoperineal Pull Through Operation: the Cleveland Clinic Experience in the 21 Century.

May 02, 2022

The Turnbull Cutait pull-through procedure (TCO) restores intestinal continuity in the setting of chronic pelvic sepsis, colorectal anastomotic leak, complex pelvic fistulas, and technical challenges ...

MicroRNA-449c-5p alleviates lipopolysaccharide-induced HUVECs injury via inhibiting the activation NF-κb signaling pathway by TAK1.

Apr 18, 2022

Acute kidney injury caused by sepsis has become a hotspot of scientific research in recent years. Since the kidney is the most abundant of all organs with vascular endothelium, activation and injury o...

Biogeochemical impacts of sewage effluents in predominantly rural river catchments: Are point source inputs distinct to background diffuse pollution?

Mar 21, 2022

Discharge of treated sewage effluent to rivers can degrade aquatic ecosystem quality, interacting with multiple stressors in the wider catchment. In predominantly rural catchments, the river reach inf...

Structure-based molecular characterization of the LltR transcription factor from Listeria monocytogenes.

Feb 28, 2022

Listeria monocytogenes is a psychrotrophic food-borne pathogenic bacterium that causes listeriosis. Due to its unusual adaptation, an ability to grow at extended temperatures ranging from 4 to 45 °C...

Co-occurrence of odor-causing dioxanes and dioxolanes with bis(2-chloro-1-methylethyl) ether in Huangpu River source water and fates in O-BAC process.

Feb 21, 2022

In recent years, dioxanes and dioxolanes have been intermittently detected in water environment and have caused several offensive drinking water odor incidents worldwide. In this study, the co-occurre...

Minocycline Pretreatment Prevents Blood-Brain Barrier Disruption in Septic Rats.

Feb 14, 2022

The aim of the study was to explore the mechanism by which minocycline protects the blood-brain barrier (BBB) in septic rats.A sepsis rat model was generated in healthy, male Sprague-Dawley rats by ce...

Bone mesenchymal stem cell-derived extracellular vesicles inhibit DAPK1-mediated inflammation by delivering miR-191 to macrophages.

Feb 14, 2022

Alveolar macrophage activation and apoptosis are vital contributors to sepsis-associated acute lung injury (ALI). However, the mechanisms of alveolar macrophage activation are yet to be clarified. Dea...

Eosinophil Cell Count Predicts Mortality in the Intensive Care Unit after Return of Spontaneous Circulation.

Jan 31, 2022

Eosinophils constitute 1%-5% of peripheral blood leukocytes, less in the presence of acute infections (referred to as eosinopenia). Studies indicate that eosinopenia can be used as a prognostic predic...

Phase I Trial of Definitive Concurrent Chemoradiotherapy and Trametinib for KRAS-Mutated Non-Small Cell Lung Cancer.

Jan 24, 2022

This phase I trial (NCT01912625) evaluated the safety and pharmacokinetics of definitive concurrent chemoradiotherapy (cCRT) and the radiosensitizer trametinib (MEK1/2 inhibitor) for KRAS-mutated nonm...

The effectiveness of branching simulations in improving nurses' knowledge, attitudes, practice, and decision-making related to sepsis assessment and management.

Jan 24, 2022

Nurses have a key role in the early assessment and management of sepsis, which is crucial for optimal quality of care and better patient outcomes. However, sepsis in critical care patients is underrec...

Autotransfusion of vaginally shed blood as a novel therapy in obstetric hemorrhage: A case series.

Jan 10, 2022

To report maternal outcomes in a cohort of women who received autotransfusion of vaginally shed blood and to describe the feasibility of blood collection and cell salvage processing at the time of vag...

CircRNAPTK2 Promotes Cardiomyocyte Apoptosis in Septic Mice by Competitively Binding to miR-29b-3p with BAK1.

Dec 20, 2021

Sepsis is a predominant reason for the growing morbidity and mortality in the world. The role of circular RNAs (CircRNAs) is actively researched in sepsis. In this study, we attempt to find out the ef...

A cohort study investigating the occurrence of differences in care provided to men and women in an intensive care unit.

Dec 06, 2021

It has been reported that there are differences in the care given within the intensive care unit (ICU) between men and women. The aim of this study is to investigate if any differences still exist bet...

Results of surgical treatment in chronic anal fissure complicated by abscess or fistula in a retrospective cohort of patients.

Nov 29, 2021

We report the results of the surgical treatment of anal fissures complicated by abscess or fistula and formulate hypotheses about their nature. Among patients operated between 2012 and 2020 for anal f...