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Sepsis

Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics.

Aug 30, 2021

Lipopolysaccharides (LPS) are the main components of the external leaflet of the Gram-negative outer membrane and consist of three different moieties: lipid A, core oligosaccharide, and O-polysacchari...

Cefiderocol: A Review in Serious Gram-Negative Bacterial Infections.

Aug 26, 2021

Intravenous cefiderocol (Fetroja; Fetcroja) is the first siderophore cephalosporin approved for the treatment of adults with serious Gram-negative bacterial infections. Cefiderocol is stable against a...

Cecal perforation secondary to fungal necrotizing enterocolitis in a premature neonate.

Aug 26, 2021

Necrotizing enterocolitis (NEC) remains one of the most critical gastrointestinal comorbidities associated with neonatal prematurity and low birth weight. Despite extensive research and innovations fo...

Initial fluid resuscitation (30 mL/kg) in patients with septic shock: More or less?

Aug 26, 2021

The 2018 Surviving Sepsis Campaign (SSC) recommends rapid administration of 30 mL/kg crystalloid fluids for hypotension or lactate ≥4 mmol/L in patients with septic shock; however, there is limite...

Out-of-hospital sepsis recognition by paramedics improves the course of disease and mortality: A single center retrospective study.

Aug 23, 2021

Early recognition of sepsis and a prompt initiation of goal-directed therapy is important for sepsis survival. Little is known about the impact of early recognition of sepsis in the out-of-hospital se...

Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis.

Aug 19, 2021

Systemic inflammatory response syndrome is a major feature of sepsis which is one of the major causes of death worldwide. It has been reported that 3,5-diaryl-4,5-dihydropyrazole and thiazole derivati...

Using Electronic Health Record Tools to Decrease Antibiotic Exposure in Infant Sepsis Evaluation.

Aug 16, 2021

Our internal infant sepsis evaluation clinical practice guideline recommends infants with negative culture results who are undergoing sepsis evaluation receive antibiotics until culture results are ne...

Senescence-associated hyper-activation to inflammatory stimuli .

Aug 12, 2021

Aging is associated with an increased susceptibility to adverse inflammatory conditions such as sepsis and cytokine storm. We hypothesized that senescent cells (SnCs) play a central role in this age-a...

Surgical management of chronic pulmonary aspergillosis in Africa: a systematic review of 891 cases.

Aug 09, 2021

Chronic pulmonary aspergillosis (CPA) is an emerging fungal infectious disease of public health importance. We conducted a systematic review of studies reporting the outcomes of patients with CPA mana...

Faecal sludge pyrolysis: Understanding the relationships between organic composition and thermal decomposition.

Aug 09, 2021

Sludge treatment is an integral part of faecal sludge management in non-sewered sanitation settings. Development of pyrolysis as a suitable sludge treatment method requires thorough knowledge about th...

Activation of CB2 receptor inhibits pyroptosis and subsequently ameliorates cecal ligation and puncture-induced sepsis.

Aug 09, 2021

Cannabinoid receptor 2 (CB2), whose activities are upregulated during sepsis, may be related to the regulation of inflammatory programmed cell death called pyroptosis. The aim of this study is to inve...

HSPA12A improves endothelial integrity to attenuate lung injury during endotoxemia through activating ERKs and Akt-dependent signaling.

Aug 05, 2021

Acute lung injury (ALI) is a critical manifestation of sepsis/septic shock. Disruption of endothelial barrier function is critical for ALI pathogenesis; however, the regulation of endothelial barrier ...

Sepsis and Kidney Injury.

Aug 05, 2021

Clinical Background: Clinical infections and its most severe forms sepsis and septic shock are commonly associated with changes in kidney function. This acute kidney injury (AKI) is associated with in...

Feasibility study evaluating a veterinary point-of-care urine culture system for diagnosing septic peritonitis.

Aug 02, 2021

To evaluate the use of a veterinary point-of-care urine culture system (POCUCS) for the diagnosis of septic peritonitis.Prospective feasibility study performed between August 2017 and April 2018.Priva...

Sialic acid-conjugate modified doxorubicin nanoplatform for treating neutrophil-related inflammation.

Aug 02, 2021

Neutrophils, the most abundant leukocytes in human peripheral blood, are important effector cells that mediate the inflammatory response. During neutrophil dysfunction, excessive activation and uncont...

Analyzing Serious Infections in Patients With Gout

Jul 30, 2021

Gout is the most common type of inflammatory arthritis in adults, and gout-related use of the emergency department or inpatient care has a significant cost burden, explains Jasvinder A. Singh, MBBS, M...

Nephrologist Interventions to Avoid Kidney Replacement Therapy in Acute Kidney Injury.

Jul 29, 2021

Based on the pathophysiology of acute kidney injury (AKI), it is plausible that certain early interventions by the nephrologist could influence its trajectory. In this study, we investigated the impac...

Hematopoietic Stem Cell Transplantation For Patients With Autosomal Recessive Complete Interferon Gamma Receptor 2 Deficiency: Experience In Oman.

Jul 26, 2021

Autosomal recessive complete interferon- gamma receptor-2 (IFN-γR2) deficiency is a rare potentially fatal primary immune deficiency that predisposes to disseminated mycobacterial disease.Hematopoiet...

The effect of influenza and pneumococcal vaccination in the elderly on health service utilisation and costs: a claims data-based cohort study.

Jul 22, 2021

To date, cost-effectiveness of influenza and pneumococcal vaccinations was assumed in several health economic modelling studies, but confirmation by real-world data is sparse. The aim of this study is...

Automatic continuous EEG signal analysis for diagnosis of delirium in patients with sepsis.

Jul 22, 2021

In critical care, continuous EEG (cEEG) monitoring is useful for delirium diagnosis. Although visual cEEG analysis is most commonly used, automatic cEEG analysis has shown promising results in small s...