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Sepsis

Genomic analysis of a multidrug-resistant Brucella anthropi strain isolated from a 4-day old neonatal sepsis patient.

Jul 19, 2021

Brucella anthropi is a gram negative, aerobic, motile, oxidase-positive, non-fermentative alphaproteobacteria belonging to the family Brucellaceae. It is most commonly found in the soil but is an emer...

Standardized treatment protocol for necrotizing otitis externa: retrospective case series and systematic literature review.

Jul 19, 2021

In the literature, there is no consensus on the most effective treatment protocol for Necrotising otitis externa (NOE). This article aims to produce a NOE treatment protocol from literature and clinic...

A quality improvement project to reduce antibiotic utilization and ancillary laboratory tests in the appraisal of early-onset sepsis in the NICU.

Jul 19, 2021

Diagnosis and treatment of early-onset sepsis (EOS) of the newborn remains a controversial issue among providers due to the non-infectious symptomology which exists in the newborn period.Pre/post inte...

Protective effects of Nrf2 against sepsis-induced hepatic injury.

Jul 12, 2021

This study was designed to investigate the changes of liver injury and Nrf2 signaling pathway in the process of sepsis. We also aimed to examine the role of Nrf2 in resisting oxidative stress and reli...

Luteolin activates Tregs to promote IL-10 expression and alleviating caspase-11-dependent pyroptosis in sepsis-induced lung injury.

Jul 12, 2021

Acute respiratory distress syndrome (ARDS) is characterized by an excessive pulmonary inflammatory response. Pyroptosis is a newly form of programmed inflammatory cell death that is triggered by infla...

New insights into lipopolysaccharide inactivation mechanisms in sepsis.

Jul 08, 2021

The complex pathophysiology of sepsis makes it a syndrome with limited therapeutic options and a high mortality rate. Gram-negative bacteria containing lipopolysaccharides (LPS) in their outer membran...

Effects of different lipid emulsions on serum adipokines, inflammatory markers and mortality in critically ill patients with sepsis: A prospective observational cohort study.

Jul 08, 2021

Intravenous lipid emulsions in parenteral nutrition may cause different metabolic responses and immune effects in critically ill patients with sepsis. The aim of this study is to investigate the effec...

Home parenteral nutrition patients on mixed oil lipid emulsion have a higher rate of hospitalizations compare to those on soybean oil- a prospective 2-year cohort study.

Jul 08, 2021

Mixed oil intravenous lipid emulsion (MO ILE) that contains 30% soybean oil (SO), 30% medium chain triglycerides, 25% olive oil and 15% fish oil can benefit hospitalized patients receiving parenteral ...

Predictors of survival in older adults hospitalized with COVID-19.

Jul 05, 2021

This study was designed to investigate clinical characteristics associated with mortality and predictors of survival in older adults hospitalized with COVID-19 with a focus on neurological comorbiditi...

Safety and efficacy of ultrasound-guided low-pressure perfusion mini-percutaneous nephrolithotomy in children aged 1-7 years: a retrospective observational study.

Jul 05, 2021

This article analyzed the safety and efficacy of ultrasound-guided mini-percutaneous nephrolithotomy (MPCNL) with low-pressure perfusion for the treatment of upper urinary tract stones in children.The...

Intravenous calcitriol administration regulates the renin-angiotensin system and attenuates acute lung injury in obese mice complicated with polymicrobial sepsis.

Jul 05, 2021

Calcitriol, an active form of vitamin D, has immunomodulatory and anti-inflammatory properties. Vitamin D levels have inverse correlation with sepsis outcomes and obesity may aggravate the severity of...

Exosomal microRNA-16-5p from adipose mesenchymal stem cells promotes TLR4-mediated M2 macrophage polarization in septic lung injury.

Jul 01, 2021

Reports on septic lung injury have implicated the protective effects of adipose mesenchymal stem cells-derived Exos (ADSCs-Exos). At present, we tried to explain the mechanism of ADSCs-Exos-loaded mic...

Outcomes for Infants Born in Perinatal Centers Performing Fewer Surgical Ligations for Patent Ductus Arteriosus: A Swiss Population-Based Study.

Jun 24, 2021

To assess patent ductus arteriosus (PDA) treatment variation between Swiss perinatal centers and to determine its effect on outcome in a population-based setting.Retrospective cohort study of infants ...

A case report on non-specific synovitis of the knee due to septic foreign body in the Hoffa fat pad causing diagnostic dilemma.

Jun 24, 2021

Recurrent chronic synovitis due to foreign body is a rare entity and it may progress into chronic septic arthritis. Chronic recurrent synovitis or septic arthritis may leave permanent damage to the ar...

Maintenance treatment in relapsed canine lymphoma after a short L-CHOP protocol.

Jun 24, 2021

A number of different rescue protocols for relapsed canine multicentric large-cell lymphoma have been described. The aim of this pilot study was to evaluate the efficacy of a maintenance treatment in ...

Fatal necrotizing fasciitis in illegal abortion and the negligence tort.

Jun 17, 2021

The present paper is a case-based review on rare complications of illegal abortion, i.e., necrotizing fasciitis missed early by the treating gynecologists which landed up into a negligence tort agains...

Stimulus-Induced Rhythmic or Periodic Intermittent Discharges (SIRPIDs) in patients with triphasic waves and Creutzfeldt-Jakob disease.

Jun 17, 2021

Since the term Stimulus-Induced Rhythmic, Periodic, or Ictal Discharges (SIRPIDs) was introduced into the vocabulary of electrophysiologists/neurologists, there has been an ongoing debate about its si...

Rotational Thromboelastometry in Neonates Admitted to a Neonatal Intensive Care Unit: A Large Cross-sectional Study.

Jun 17, 2021

The aim of the present study was to assess the coagulation profile in neonatal critical illness using rotational thromboelastometry (ROTEM), and to investigate its association with disease severity an...

Sildenafil in endotoxin-induced pulmonary hypertension: an experimental study.

Jun 14, 2021

Sepsis and septic shock still represent great challenges in critical care medicine. Sildenafil has been largely used in the treatment of pulmonary arterial hypertension, but its effects in sepsis are ...

Effect of thiamine supplementation in critically ill patients: A systematic review and meta-analysis.

Jun 14, 2021

Several studies have previously shown the benefit of thiamine supplementation in critically ill patients. In order to fully appraise the available data, we performed a meta-analysis of 18 published st...