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Skin Cancer

Toripalimab Plus Paclitaxel and Carboplatin as Neoadjuvant Therapy in Locally Advanced Resectable Esophageal Squamous Cell Carcinoma.

Mar 21, 2022

Immune checkpoint inhibitors (ICIs) are effective in the treatment of advanced esophageal squamous cell carcinoma (ESCC); however, their efficacy in locally advanced resectable ESCC and the potential ...

Evolution of bone metastases in patients receiving at least three months of checkpoint inhibitors.

Mar 21, 2022

To investigate the evolution of bone metastases in patients receiving immune checkpoint inhibitors (ICI).A single-center retrospective study included cancer patients with bone metastases treated with ...

Differential promoter usages of PTCH1 and down regulation of HHIP are associated with HNSCC progression.

Mar 14, 2022

The study was aimed to understand the importance of the hedgehog signaling pathway in development of head and neck squamous cell carcinoma (HNSCC).The molecular profiles of the key regulatory genes of...

Neoantigen Identification and Response to Adoptive Cell Transfer in anti PD-1 Naïve and Experienced Patients with Metastatic Melanoma.

Mar 07, 2022

Immune checkpoint blockade (ICB) agents and adoptive cell transfer (ACT) of tumor infiltrating lymphocytes (TIL) are prominent immunotherapies used for the treatment of advanced melanoma. Both therapi...

Single cell characterization of the cellular landscape of acral melanoma identifies novel targets for immunotherapy.

Mar 07, 2022

Acral melanoma is a rare subtype of melanoma that arises on the non-hair-bearing skin of the palms, soles and nail beds. In this study, we used single cell RNA-seq (scRNA-seq) to map the transcription...

Impact of HPV status on immune responses in head and neck squamous cell carcinoma.

Feb 28, 2022

The main objective of our study was to understand the impact of immune cell composition and the tumor-reactivity of tumor infiltrating lymphocytes (TIL) in HPV-positive (HPV) and HPV-negative (HPV) he...

Does sex matter? Analysis of sex-related differences in the diagnostic performance of a market-approved convolutional neural network for skin cancer detection.

Feb 21, 2022

Advances in biomedical artificial intelligence may introduce or perpetuate sex and gender discriminations. Convolutional neural networks (CNN) have proven a dermatologist-level performance in image cl...

Comparison between dose distribution from Pd, Cs, and I plaques in a real human eye model with different tumor size.

Feb 21, 2022

Knowledge of the energy deposition in different eye components is a critical decision-making to the overall effectivity of ocular melanoma treatment with plaques loaded with low-energy sources. The ai...

#VisualAbstract: Skin cancer risk factors and screening differ among Asian American individuals

Feb 08, 2022

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Clinical outcomes of patients with pT4a and pT4b oral cavity squamous cell carcinoma who had undergone surgery: Results from a Taiwanese registry-based, nationwide cohort study.

Feb 07, 2022

While the NCCN guidelines maintain that T4b oral cavity squamous cell carcinoma (OCSCC) should undergo either non-surgical treatments or clinical trials, promising outcomes of T4b OCSCC having surgica...

Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma.

Jan 31, 2022

Cytotoxic effects of radiation play an important role in the treatment of head and neck cancer. However, irradiation is known to lead to the migration of various cancer cells, including those of head ...

Immunological significance of survival-related alternative splicing in uveal melanoma.

Jan 24, 2022

Uveal melanoma (UM) is a highly malignant intraocular tumor. The imbalance of alternative splicing (AS) is a landmark of tumor initiation and progression. However, there are few studies of AS in UM. T...

Tumour- associated autoantibodies as prognostic cancer biomarkers- a review.

Jan 17, 2022

Throughout the process of carcinogenesis, autologous cells are transformed into cancer cells, leading to changes in their protein expression profiles. It has been suggested that mutations, protein mis...

An injectable superior depot of Telratolimod inhibits post-surgical tumor recurrence and distant metastases.

Jan 17, 2022

The clinical success of Toll-like receptor (TLR) agonists is based on their capacity to efficiently mobilize both innate and adaptive immunity. However, rapid distribution of TLR agonists into the sys...

Changing characteristics, treatment approaches and survival of patients with brain metastasis: data from six thousand and thirty-one individuals over an observation period of 30 years.

Jan 10, 2022

An accurate classification of patients with brain metastases (BMs) is an important foundation to guide individualised treatment decisions and to formulate BM cohorts for modern clinical trials.Six tho...

Closure of radial forearm free flap donor-site defect with proportional local full-thickness skin graft: case series study of a new design.

Jan 03, 2022

The aim of this study was to describe a simple, convenient, and reliable new technique using local full-thickness skin graft (FTSG) for skin coverage of a donor-site defect of the radial forearm free ...

PD-L1 expression is regulated by microphthalmia-associated transcription factor (MITF) in nodular melanoma.

Dec 27, 2021

Malignant melanoma (MM) is known to avoid the host's immune response. Studies on in vitro melanoma cell lines link the microphthalmia-associated transcription factor (MITF) with the regulation of the ...

Role of Esophagectomy after Chemoradiation Therapy in Patients with Locally Advanced Squamous Cell Carcinoma: A Comparative Analysis Stratified by Clinical Response to Chemoradiation Therapy.

Dec 27, 2021

This study aimed to evaluate the long-term effect of esophagectomy in patients with esophageal squamous cell carcinoma (ESCC) by comparing the chemoradiotherapy (CRT)-only group and the trimodality tr...

Multifunctional Immunoliposomes Enhance the Immunotherapeutic Effects of PD-L1 Antibodies against Melanoma by Reprogramming Immunosuppressive Tumor Microenvironment.

Dec 20, 2021

The immunosuppressive tumor microenvironment (TME) can significantly limit the immunotherapeutic effects of the PD-L1 antibody (aPDL1) by inhibiting the infiltration of CD8 cytotoxic T cells (CTLs) in...

Lighter Eye Color Linked With Increased Risk for Skin Cancer

Dec 13, 2021

“Lighter pigmentary traits, such as lighter hair, lighter skin, and severe skin reaction following sun exposure, have been tied to higher risk for skin cancers,” explains Eunyoung Cho, ScD. “How...

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