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Skin Cancer

Antioxidant and Anti-Melanogenic Activities of Heat-Treated Licorice (Wongam, × ) Extract.

Sep 27, 2021

Melanin is a brown or black pigment that protects skin from ultraviolet radiation and reactive oxygen species (ROS). However, overproduction of melanin is associated with lentigines, melasma, freckles...

Interleukin-6 blockade for prophylaxis and management of immune-related adverse events in cancer immunotherapy.

Sep 20, 2021

Immune checkpoint inhibitors (ICIs) have activity across many tumor types, but activation of the immune system may also lead to significant, often steroid-refractory immune-related adverse events (irA...

A photoactivatable chemotherapeutic Ru(II) complex bearing bathocuproine ligand efficiently induces cell death in human malignant melanoma cells through a multi-mechanistic pathway.

Sep 13, 2021

Photoactivated chemotherapy (PACT) is an emerging strategy for targeted cancer therapy. Strained Ru complexes with pseudo-octahedral geometry may undergo photo-induced ligand dissociation, forming aqu...

Skin cancer classification via convolutional neural networks: systematic review of studies involving human experts.

Sep 13, 2021

Multiple studies have compared the performance of artificial intelligence (AI)-based models for automated skin cancer classification to human experts, thus setting the cornerstone for a successful tra...

The impact of positive margin on survival in oral cavity squamous cell carcinoma.

Sep 13, 2021

Positive margins are known to impact survival in oral cavity squamous cell carcinoma (OCSCC). We aimed to determine the impact of positive margins on survival and whether radiation improves survival f...

Malignant melanoma of the prostate gland: A systematic review.

Sep 06, 2021

Prostatic melanoma is a rare malignancy about which only scattered case reports and no systematic reviews have been published to date. We sought to better inform clinicians and pathologists caring for...

An unsupervised method for histological image segmentation based on tissue cluster level graph cut.

Sep 06, 2021

While deep learning models have demonstrated outstanding performance in medical image segmentation tasks, histological annotations for training deep learning models are usually challenging to obtain, ...

MVAΔ008 viral vector encoding the model protein OVA induces improved immune response against the heterologous antigen and equal levels of protection in a mice tumor model than the conventional MVA.

Sep 06, 2021

Modified vaccinia Ankara virus (MVA) is extensively used as a vaccine vector. We have previously observed that MVAΔ008, an MVA lacking the gene that codes for interleukin-18 binding protein, signific...

The gut microbiome and efficacy of cancer immunotherapy.

Aug 30, 2021

Cancer treatment has been deeply changed by immunotherapy, achieving unprecedented improvement in overall and progression-free survival in several advanced and metastatic cancers. Currently, immune ch...

Real-life data for first-line combination immune-checkpoint inhibition and targeted therapy in patients with melanoma brain metastases.

Aug 30, 2021

Melanoma brain metastases (MBM) have a poor prognosis. Systemic treatments that have improved outcomes in advanced melanoma have been shown to have an intracranial (IC) effect. We studied the efficac...

An overview of the current clinical status of optical imaging in head and neck cancer with a focus on Narrow Band imaging and fluorescence optical imaging.

Aug 30, 2021

Early and accurate identification of head and neck squamous cell carcinoma (HNSCC) is important to improve treatment outcomes and prognosis. New optical imaging techniques may assist in both the diagn...

Myasthenia Gravis Lambert-Eaton overlap syndrome induced by nivolumab in a metastatic melanoma patient.

Aug 26, 2021

Myasthenia gravis (MG) Lambert-Eaton (LE) overlap syndrome is a rare condition. Here, we describe the first case of MG-LE overlap syndrome revealed by the anti-programmed cell death 1 inhibitor, nivo...

Randomized controlled trial of fractionated laser resurfacing to aged skin as prophylaxis against actinic neoplasia.

Aug 26, 2021

The loss of insulin-like growth factor-1 (IGF-1) expression in senescent dermal fibroblasts during aging is associated with an increased risk of non-melanoma skin cancer (NMSC). We tested how IGF-1 si...

A Large Oral Melanoma: A Case Report of a Rare but Aggressive Malignancy.

Aug 26, 2021

A variety of black-pigmented lesions of the oral cavity can be found, ranging from harmless benign lesions such as melanotic macule, smoker's melanosis, amalgam/graphite tattoos, and pigmented nevus t...

Trichoblastoma mimicking basal cell carcinoma and the approach to its management: Case report.

Aug 23, 2021

Trichoblastoma is a benign and rare cutaneous lesion with striking resemblance to basal cell carcinoma. However, the course of the illness varies significantly from basal cell carcinoma. It usually ta...

Risk factors for gastrostomy tube dependence in transoral robotic surgery patients.

Aug 23, 2021

To determine the rate of gastrostomy tube dependence after transoral robotic surgery (TORS), and to determine which patient or surgical factors increase the likelihood of gastrostomy tube dependence.R...

Primary lung carcinoma in children and adolescents - Clinical characteristics and outcome of 12 cases from the German registry for rare paediatric tumours (STEP).

Aug 23, 2021

Primary lung carcinomas are very rare paediatric tumours with an incidence of < 2/1.000.000 per year. They are clinically and histologically heterogeneous, and there are no therapeutic guidelines...

Impact of sarcopenia in locally advanced head and neck cancer treated with chemoradiation: An Indian tertiary care hospital experience.

Aug 19, 2021

Sarcopenia is emerging as a poor prognostic factor in terms of treatment outcome as well as complications in cancer patients. This study aims to determine the prevalence of sarcopenia and its impact o...

Prognostic impact and potential predictive role of baseline circulating tumor cells in locally advanced head and neck squamous cell carcinoma.

Aug 19, 2021

The prognostic impact of circulating tumor cells (CTCs) or circulating tumor microemboli (CTM) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is yet to be determined, with confli...

Is there a role for Gallium-67 SPECT in distinguishing progression and pseudoprogresion in oncologic patients receiving immunotherapy?

Aug 19, 2021

Immuno-oncology (IO) with immune checkpoint inhibitors (ICIs) is the new landmark in cancer treatment. However, due to its economical-related burden and the possibility of tumor pseudoprogression with...

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