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Skin Cancer

Non-small cell lung carcinoma histopathological subtype phenotyping using high-dimensional multinomial multiclass CT radiomics signature.

Aug 16, 2021

The aim of this study was to identify the most important features and assess their discriminative power in the classification of the subtypes of NSCLC.This study involved 354 pathologically proven NSC...

Methanol extract of Sedum oryzifolium and its constituent, trehalose, impede the invasiveness of oral squamous cell carcinoma cell lines via downregulation of Slug.

Aug 16, 2021

Sedum species are reported to possess diverse pharmacological activities in various solid tumors. However, the anticancer functions of Sedum orizyfolium and its constituents have never been determined...

In situ DESI-MSI lipidomic profiles of mucosal margin of oral squamous cell carcinoma.

Aug 16, 2021

Although there is consensus that the optimal safe margin is ≥ 5mm, obtaining clear margins (≥5 mm) intraoperatively seems to be the major challenge. We applied a molecular diagnostic method at the...

Genetic variants of SDCCAG8 and MAGI2 in mitosis-related pathway genes are independent predictors of cutaneous melanoma-specific survival.

Aug 12, 2021

Mitosis is a prognostic factor for cutaneous melanoma (CM), but accurate mitosis detection in CM tissues is difficult. Therefore, the 8th Edition of the American Joint Committee on Cancer staging syst...

Efficacy of Non-excisional Treatment Modalities for Superficially Invasive and In Situ Squamous Cell Carcinoma: A Systematic Review and Meta-analysis.

Aug 12, 2021

Squamous cell carcinoma in situ (SCCIS) and squamous cell carcinoma (SCC) are prevalent conditions that are increasing in incidence worldwide. Many non-excisional treatments are commonly used, but the...

The Genetics of Uveal Melanoma: Overview and Clinical Relevance.

Aug 12, 2021

Over the last ten years, much has been learnt about the genetic characteristics and genetic evolution of uveal melanoma. It has been shown that uveal melanoma differs fundamentally from non-uveal mela...

SERS-based DNA methylation profiling allows the differential diagnosis of malignant lymphadenopathy.

Aug 09, 2021

This study highlights the potential of surface-enhanced Raman scattering (SERS) to differentiate between B-cell lymphoma (BCL), T-cell lymphoma (TCL), lymph node metastasis of melanoma (Met) and contr...

Baicalin exerts anti-tumor effects in oral squamous cell carcinoma by inhibiting the microRNA-106b-5p-Wnt/β-catenin pathway via upregulating disabled homolog 2.

Aug 09, 2021

The aim of this study was to investigate the role and molecular regulatory mechanisms of baicalin in oral squamous cell carcinoma (OSCC) progression.Gene expression in OSCC cells was detected by quant...

Clinicopathologic Characteristics and Prognostic Factors Impacting Survival in Melanoma of the Eyelid: Running Title: Prognostic Factors for Survival in Melanoma of the Eyelid.

Aug 05, 2021

To examine prognostic factors for survival in patients with melanoma of the eyelid.Retrospective cohort analysis SETTING: Population-based study STUDY POPULATION: Patients with primary melanoma of the...

A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.

Aug 05, 2021

Genome-wide association studies (GWASs) have identified a melanoma-associated locus on chromosome band 7p21.1 with rs117132860 as the lead SNP and a secondary independent signal marked by rs73069846. ...

CPOP: An open source C++ cell POPulation modeler for radiation biology applications.

Aug 05, 2021

Multicellular tumor spheroids are realistic in-vitro systems used in radiation biology research to study the effect of anticancer drugs or to evaluate the resistance of cancer cells under specific con...

Evaluation of the oncolytic property of recombinant Newcastle disease virus strain R2B in 4T1 and B16-F10 cells in-vitro.

Aug 02, 2021

Recombinant Newcastle disease virus vectors have gained a lot of interest for its oncolytic virus therapy and cancer immune therapeutic properties due to its selective replication to high titers in ca...

A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma.

Aug 02, 2021

An antibody-drug conjugate (ADC) is a promising therapeutic modality because selective and effective delivery of an anti-cancer drug is achieved by drug-conjugated antibody-targeting cancer antigen. G...

Single-port robotic inguinal lymph node dissection: A safe and feasible option for penile cancer.

Aug 02, 2021

Inguinal lymph node dissection (ILND) is essential to the accurate staging of advanced penile cancer and in determining prognosis. Open ILND is associated with significant morbidity. The robotic-assis...

Pyk2 level is a novel prognostic marker for patients with esophageal squamous cell carcinoma after radical surgery.

Jul 29, 2021

Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors in East Asia. Surgical resection is currently the typical treatment. However, due to the highly invasive and metast...

MPI-based bioinformatic analysis and co-inhibitory therapy with mannose for oral squamous cell carcinoma.

Jul 29, 2021

Mannose induces tumor cell apoptosis and inhibits glucose metabolism by accumulating intracellularly as mannose 6-phosphate while the drug sensitivity of tumors is negatively correlated with mannose p...

Squamoid Eccrine Ductal Carcinoma.

Jul 29, 2021

Squamoid eccrine ductal carcinoma (SEDC) is a rare and under-recognized primary cutaneous tumor with a high risk for local recurrence and metastasis. The tumor has a biphasic histologic appearance con...

Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 Study): an open-label, nonrandomized, multicenter, phase 2 trial.

Jul 26, 2021

Pembrolizumab demonstrated clinically meaningful and durable antitumor activity with a manageable safety profile in recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (cSCC).KEYNOTE-629 was ...

Dose characteristics of Au-198 eye brachytherapy applicator: A Monte Carlo study.

Jul 26, 2021

The use of ocular plaques is a promising treatment option for eye melanoma brachytherapy. Although several studies have been done on various ocular plaques, little is known about the dose characteriza...

Anatomic Distribution of Cherry Angiomas in the General Population.

Jul 26, 2021

Cherry angiomas are common benign vascular skin lesions of unknown aetiology, found largely on the trunk. However, their exact anatomic distribution besides their truncal predisposition, and how they ...

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