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Endocrinology General

HIF-2 Protects Mitochondrial Activity and Glucose Sensing in Obese Compensating -Cells

Jul 06, 2022

Obesity causes mitochondrial damage and β-cell dysfunction due to increased mitochondrial metabolism and the buildup of oxidative stress. β-cells, in particular, express antioxidant enzymes at low q...

PYY-Induced Nausea is Inhibited by GIPR Agonism

Jul 05, 2022

The generation of nausea and emesis is a significant obstacle to optimizing the weight loss profile of obesity drugs; hence, discovering strategies that increase tolerability might result in further t...

Mir-125b, Which is Glucose-Dependent, Is a Negative Regulator of Β-Cell Function

Jul 05, 2022

Type 2 diabetes is characterized by impaired insulin production and pancreatic beta-cell activity. MiRNAs are small, non-coding RNAs that inhibit gene expression necessary for cell growth and function...

Follow-up Frequency & Clinical Outcomes in Type 2 Diabetes Patients: A Prospective Study Using Multicenter Real-World Data

Jun 22, 2022

For a study, researchers sought to see if the frequency of follow-up for type 2 diabetes mellitus (T2DM) patients in National Metabolic Management Centers (MMCs) results in different clinical outcomes...

Obesity Drastically Increases Complex Multimorbidity Risk

Jun 21, 2022

The powerful link between obesity and multimorbidities is a critical target for disease prevention that avoids the burden of multi-target preventive measures. Obesity is a shared risk factor fo...

In Pancreatic β-cell, PTPN2 Regulates Interferon Signaling & ER Stress Response

Jun 10, 2022

T1D is caused by the autoimmune destruction of β-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are T1D candidate genes that play an important role in developing autoimmune illness and ...

Islet Autoimmunity: Diminished β-Cell Function in T2D Patients

Jun 10, 2022

Autoimmunity to the islets may lead to β-cell dysfunction in type 2 diabetes (T2D). However, its frequency and clinical relevance have yet to be identified. For a study, researchers assessed the inci...

Hyperglycemia, Reduced Hematopoietic Stem Cells, & COVID-19 Outcome

Jun 10, 2022

Admission hyperglycemia has emerged as a predictor of poor global coronavirus disease 2019 (COVID-19) outcomes. Hyperglycemia causes a decrease in the number of circulating hematopoietic stem/progenit...

Microaneurysm Pathophysiology in Diabetic Retinopathy

Jun 10, 2022

In diabetic retinopathy, microaneurysms are indicators of microvascular damage (DR). A major pathogenic factor in the development of microvascular disorders was impaired retinal capillary perfusion. H...

Genetic Predictors of Change in WC & Waist-to-Hip (WTH) Ratio

Jun 10, 2022

Single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI) have been identified in genome-wide association s...

Lactate Links Obesity to Insulin Resistance via Modulating Cytokine Production

Jun 10, 2022

Numerous studies have found that inflammation in adipose tissue is the major source of obesity-induced systemic insulin resistance. Obesity-related changes in circulating LPS levels, as well as hypoxi...

Understanding the Functions of Genes Disrupted in Lipodystrophy

Jun 10, 2022

Lipodystrophy syndromes are disorders in which an individual's adipose tissue mass is abnormally changed. A shift in adipose mass can range from a minor redistribution in some people with partial lipo...

Diabetes-Induced Cellular Senescence and SASP

Jun 10, 2022

Diabetes influences the biology of multipotent cardiac stem/progenitor cells (CSCs) and adult myocardial regeneration. Therefore, the idea was tested that senescence and senescence-associated secretor...

The Essential Role of Pancreatic α-Cells in Maternal Metabolic Adaptation to Pregnancy

Jun 08, 2022

Although pancreatic α-cells play a vital role in maintaining metabolic homeostasis, little is known about their involvement in regulating maternal metabolic responses to pregnancy. For a study, resea...

Obesity-Associated Genes in Young Adults With Severe Obesity

Jun 08, 2022

Recent improvements in genetic analysis have considerably aided in gradually narrowing the obesity heritability gap and bringing to light monogenic variations that alter melanocortin signaling. In pri...

Understanding the Functions of Genes Disrupted in Lipodystrophy

Jun 08, 2022

Lipodystrophy syndromes are disorders in which an individual's adipose tissue mass is abnormally changed. A shift in adipose mass can range from a minor redistribution in some people with partial lipo...

Sparking Positive Dialogue in Women & Men With Obesity

Jun 06, 2022

While obesity is a chronic, complex disease that can affect anyone, it impacts men and women differently. Although the proportion of men and women with excess weight is about equal, the severity is di...

DOC2b: β-Cell Function & Novel Tyrosine Phosphorylation-Dependent Mechanism

May 31, 2022

The protein Double C2 domain B (DOC2b) is essential for glucose-stimulated insulin secretion (GSIS) in β-cells. However, the underlying mechanism was unknown. Using primary human islets and human an...

Fat Distribution Within the Pancreas According to Diabetes Status & Insulin Traits

May 27, 2022

A rising body of data implied that intrapancreatic fat is connected with diabetes, however, it is uncertain whether intrapancreatic fat distribution throughout pancreatic areas has a pathophysiologic ...

Maternal Exercise-Induced SOD3: Negative Effects of High-fat Diet on Offspring Metabolism

May 27, 2022

Preclinical research suggested that maternal exercise is a viable strategy for reducing the transmission of intergenerational metabolic dysfunction induced by maternal obesity. The advantages of mater...