Advertisement

Osteoporosis

Systematic review and meta-analysis of cardiovascular risk in rheumatological disease: Symptomatic and non-symptomatic events in rheumatoid arthritis and systemic lupus erythematosus.

Aug 30, 2021

Although each autoimmune disease is associated with specific tissue or organ damage, rheumatic diseases share a pro-inflammatory pattern that might increase cardiovascular risk. Retrospective and pros...

Inhibition of glycolysis in the presence of antigen generates suppressive antigen-specific responses and restrains rheumatoid arthritis in mice.

Aug 30, 2021

Dendritic cells (DCs) rely on glycolysis for their energy needs to induce pro-inflammatory antigen-specific immune responses. Therefore, inhibiting DC glycolysis, while presenting the self-antigen, ma...

T-Cell Immune Imbalance in Rheumatoid Arthritis Is Associated with Alterations in NK Cells and NK-Like T Cells Expressing CD38.

Aug 26, 2021

CD38+ NK (CD3- CD16+ CD38+ CD56+) cells were increased in rheumatoid arthritis (RA), which suppressed Treg cell differentiation. This study explored how CD38+ NK cells regulated CD4+ T-cell differenti...

Impact of maternal autoimmune disease on cell-free DNA test characteristics.

Aug 23, 2021

Maternal biologic factors can affect fetal fraction in cell-free DNA-based prenatal screening assays, thereby limiting effectiveness. Higher rates of indeterminate results from low fetal fraction have...

Biomechanical evaluation of oblique lumbar interbody fusion stand alone under three different bone mineral density conditions: A finite element analysis.

Aug 23, 2021

To evaluate the biomechanical stability of oblique lumbar inter-body fusion stand-alone (OLIF SA) under different bone mineral density (BMD) conditions and analyze the effect of different BMD conditio...

Autoimmune diseases in patients undergoing percutaneous coronary intervention: A risk factor for in-stent restenosis?

Aug 23, 2021

Despite the relation between autoimmune diseases and increased atherosclerotic risk is established, the influence of autoimmune disorders on in-stent restenosis (ISR) after percutaneous coronary inter...

The risk of serious infection in rheumatoid arthritis patients receiving tocilizumab compared with tumor necrosis factor inhibitors in Korea.

Aug 19, 2021

To examine the risk of serious infections (SIs) among patients with rheumatoid arthritis (RA) treated with tocilizumab compared with tumor necrosis factor inhibitor (TNFi) in Korea.We conducted a retr...

Chronic inflammation and extracellular matrix-specific autoimmunity following inadvertent periarticular influenza vaccination.

Aug 19, 2021

Viral infections may trigger autoimmunity in genetically predisposed individuals. Immunizations mimic viral infections immunologically, but only in rare instances vaccinations coincide with the onset ...

Health-Related Quality of Life in Psoriatic Arthritis: Findings and Implications.

Aug 16, 2021

To assess the quality of life (QOL) and its associated factors in patients with psoriatic arthritis (PsA) who would start treatment with biologic drugs at the Brazilian Unified Health System.A cross-s...

Characterization and comparison of hyper-viscoelastic properties of normal and osteoporotic bone using stress-relaxation experiment.

Aug 16, 2021

Bone tissue behavior under various loads is nonlinear elastic due to irreversible energy absorption. Also, viscoelasticity is one of the most important properties of bone which is very important in dy...

Mutual-reinforcing sonodynamic therapy against Rheumatoid Arthritis based on sparfloxacin sonosensitizer doped concave-cubic rhodium nanozyme.

Aug 16, 2021

Rheumatoid arthritis (RA) is an autoimmune disease associated with synovitis and cartilage destruction. Ultrasound (US)-driven sonodynamic therapy (SDT) possess a good application prospect in RA thera...

Role of Cissus quadrangularis in the Management of Osteoporosis: An Overview.

Aug 12, 2021

This article aims to provide a comprehensive review of Cissus quadrangularis (CQ), which is a traditional medicinal herb and has a potential osteoprotective effect. CQ is a perennial climber of family...

The mA methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes.

Aug 12, 2021

Mitochondrial biogenesis and energy metabolism are essential for regulating the inflammatory state of monocytes. This state is partially controlled by peroxisome proliferator-activated receptor gamma ...

Evaluation of the cargo contents and potential role of extracellular vesicles in osteoporosis.

Aug 12, 2021

Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). Extracellular vesicles (EVs) remain unexplored in the context of osteoporosis. Towards this, EVs we...

Generation and characterization of a humanized anti-IL-17A rabbit monoclonal antibody.

Aug 09, 2021

Interleukin-17A (IL-17A) produced by Th17 cells, contributes to the pathogenesis of various autoimmune diseases by stimulating the release of cytokines and chemokines and its regulation. The anti-IL...

Cardiotrophin like cytokine factor 1 (CLCF1) alleviates bone loss in osteoporosis mouse models by suppressing osteoclast differentiation through activating interferon signaling and repressing the nuclear factor-κB signaling pathway.

Aug 09, 2021

A growing body of evidence suggests that immune factors that regulate osteoclast differentiation and bone resorption might be promising therapeutic agents for the treatment of osteoporosis. The expres...

Synthesis and kinetic characterization of hyperbolic inhibitors of human cathepsins K and S based on a succinimide scaffold.

Aug 09, 2021

Cathepsins K and S are closely related papain-like cysteine peptidases and potential therapeutic targets for metabolic and inflammatory diseases such as osteoporosis and arthritis. Here we describe th...

A Comparison of Bone Mineral Density and Its Predictors in HIV-infected and HIV-uninfected Older Men.

Aug 05, 2021

Bone health in older individuals with HIV infection is not well studied. This study aimed to compare bone mineral density(BMD), trabecular bone score(TBS), and bone markers in HIV-infected- with age-m...

Associations between osteoporosis and drug exposure: a post-marketing study of the World Health Organization pharmacovigilance database (VigiBase®).

Aug 05, 2021

Bone remodeling is a complex process, and many conditions (including drug exposure) lead to osteoporosis. Here, we sought to detect new disproportionality signals for drugs associated with osteoporosi...

A Retrospective Study of Postoperative Development of Implant-Induced Osteoporosis in Radial-Ulnar Fractures in Toy Breed Dogs Treated with Plate Fixation.

Aug 05, 2021

 This study aimed to evaluate implant-induced osteoporosis (IIO) development in toy breed dogs treated using internal fixation with digital radiographs as the index of pixel values. There were 226...