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GERD

Biological correlates before esophageal cancer screening and after diagnosis.

Aug 26, 2021

Almost 50% of the world's esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. The study was designed to evaluate the biological correla...

Potential roles of gastroesophageal reflux in patients with superficial esophageal squamous cell carcinoma without major causative risk factors.

Aug 26, 2021

Cigarette smoking, alcohol consumption, and Lugol-voiding lesions (LVLs) are the major causative risk factors of esophageal squamous cell carcinoma (ESCC); however, reports on ESCC cases unrelated to ...

Long term outcomes of sporadic large fundic gland polyps: a single-center experience.

Aug 23, 2021

Sporadic fundic gland polyps (FGP) are the most common type of gastric polyp, reported in 0.8%-1.9% of patients undergoing Esophagogastroduodenoscopy (EGD). Data on long-term outcomes of large FGP is ...

UBCH5 family members differentially impact stabilization of mutant p53 via RNF128 Iso1 during Barrett's progression to esophageal adenocarcinoma.

Aug 23, 2021

TP53 mutations underlie Barrett's (BE) progression to dysplasia and cancer. During BE progression, the ubiquitin ligase (E3) RNF128/GRAIL switches expression from isoform 2 (Iso2) to Iso1 stabilizing ...

Dupilumab for STAT3-Hyper-IgE Syndrome With Refractory Intestinal Complication.

Aug 23, 2021

STAT3 hyper-immunoglobulin E syndrome (STAT3-HIES) is a rare primary immunodeficiency syndrome characterized by elevated serum immunoglobulin E levels, eczema, recurrent skin and respiratory tract inf...

Association of gastroesophageal reflux disease with increased risk of chronic otitis media with effusion in adults: A nationwide population-based cohort study.

Aug 19, 2021

This study aimed to evaluate the risk of developing chronic otitis media with effusion (OME) in individuals with gastroesophageal reflux disease (GERD).A retrospective propensity score-matched cohort ...

Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis.

Aug 19, 2021

Chronic inflammation contributes to tumor development by creating a local microenvironment that facilitates neoplastic transformation and potentiates the progression of cancer. Esophageal cancer (EC) ...

Eosinophilic Esophagitis for the General Pediatrician.

Aug 19, 2021

This article reviews pediatric eosinophilic esophagitis (EoE), a clinicopathologic disorder with symptoms related to esophageal dysfunction and characterized by eosinophil-predominant inflammation pre...

Reflux After Sleeve Gastrectomy: An Update.

Aug 16, 2021

Modifications of gastric anatomy, function, and of the esophagogastric junction secondary to sleeve gastrectomy (SG) can worsen the symptoms of gastroesophageal reflux disease (GERD). Its late diagno...

Clonally expanded, GPR15-expressing pathogenic effector T2 cells are associated with eosinophilic esophagitis.

Aug 16, 2021

Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the recruitment of eosinophils to the esophagus, resulting in chronic inflammation. We sought to understand the cellular populat...

Post per-oral endoscopic myotomy heartburn-it's always not reflux: an expert review.

Aug 16, 2021

Patients with achalasia frequently develop gastroesophageal reflux (GER) related symptoms and complications after per oral endoscopic myotomy (POEM). Reflux symptoms are thought to be due to gastroeso...

Caffeine-Induced Severe Erosive Esophagitis.

Aug 12, 2021

Caffeine is one of the most frequently used stimulants worldwide. It is, therefore, subject to frequent intentional and unintentional misuse. However, severe erosive esophagitis due to acute caffeine ...

Characteristics and Progression of Childhood-Onset and Adult-Onset Eosinophilic Esophagitis.

Aug 12, 2021

The prevalence and incidence of eosinophilic esophagitis (EoE) has been increasing over recent years. However, the natural history remains incompletely understood particularly the differences in disea...

Increased risk of Barrett's oesophagus and related neoplasia in individuals with a positive family history.

Aug 12, 2021

Considering the poor prognosis of oesophageal adenocarcinoma (EAC), it is important to identify individuals at increased risk of developing EAC who may benefit from early detection and prevention stra...

Multichannel impedance monitoring for distinguishing nonerosive reflux esophagitis with minor changes on endoscopy in children.

Aug 09, 2021

There are reports describing the relationship between baseline impedance level and esophageal mucosal integrity at endoscopy, such as erosive and nonerosive reflux esophagitis. However, many children ...

Eosinophils and Bacteria, the Beginning of a Story.

Aug 09, 2021

Eosinophils are granulocytes primarily associated with T2 responses to parasites or immune hyper-reactive states, such as asthma, allergies, or eosinophilic esophagitis. However, it does not make sens...

Accuracy of Preoperative Endoscopy in Determining Tumor Location Required for Surgical Planning for Esophagogastric Junction Cancer.

Aug 09, 2021

The surgical strategy for esophagogastric junction (EGJ) cancer depends on the tumor location as measured relative to the EGJ line. The purpose of this study was to clarify the accuracy of diagnostic ...

Sorting out the Relationship between Gastroesophageal Reflux Disease and Sleep.

Aug 05, 2021

Gastroesophageal reflux disease is one of the most common conditions encountered by primary care physicians, gastroenterologists, foregut surgeons and otolaryngologists. While approximately 50% of pat...

Proton pump inhibitor omeprazole suppresses carcinogen induced colonic adenoma progression to adenocarcinoma in F344 rat.

Aug 05, 2021

Colorectal cancer (CRC) causes over 53,000 deaths annually in the United States. Its rising incidences worldwide and particularly in young adults is a major concern. Here, we evaluated the efficacy of...

Expression of CD44 and CD133 stem cell markers in squamous cell carcinoma of esophagus.

Aug 05, 2021

Role of cancer stem cells in the esophageal carcinogenesis is not clear.To assess the expression of CD44 and CD133 cancer stem cell markers in esophageal squamous cell carcinoma (ESCC) and its predisp...