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Irritable Bowel Syndrome / IBS

The presence of a neurodiverse disorder is associated with increased use of antegrade enema therapy in children with severe constipation: A study from the Pediatric Colorectal and Pelvic Learning Consortium (PCPLC).

May 23, 2022

Children with severe constipation and a neurodiverse disorder (Autism and/or developmental delay) represent a challenging bowel management group. Treatment outcomes with laxative or enema therapy rema...

Population Pharmacokinetic/Pharmacodynamic Joint Modeling of Ixazomib Efficacy and Safety Using Data from the Pivotal Phase 3 TOURMALINE-MM1 Study in Multiple Myeloma Patients.

May 23, 2022

Ixazomib is an oral proteasome inhibitor approved in combination with lenalidomide and dexamethasone for the treatment of relapsed/refractory multiple myeloma (MM). Approval in the United States, Euro...

Trial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis.

May 16, 2022

Phosphodiesterase 4 (PDE4) inhibition is associated with antiinflammatory and antifibrotic effects that may be beneficial in patients with idiopathic pulmonary fibrosis.In this phase 2, double-blind, ...

Evaluation of adverse events in small-breed dogs treated with maropitant and a single dose of doxorubicin.

May 09, 2022

The recommended doxorubicin (DOX) dose for small dogs is 1 mg/kg. Recent data suggest that DOX-induced gastrointestinal (GI) toxicosis can be reduced with maropitant treatment.To investigate the inci...

A therapeutic guide on pediatric irritable bowel syndrome and functional abdominal pain-not otherwise specified.

Apr 25, 2022

Disorders of the gut-brain interaction negatively impact quality of life and carry a substantial socioeconomic burden. Irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specif...

The therapeutic effect of Xuanbai Chengqi Decoction on chronic obstructive pulmonary disease with excessive heat in the lung and fu-organs based on gut and lung microbiota as well as metabolic profiles.

Apr 18, 2022

As a prescription for treating lung inflammation and intestinal diseases, Xuanbai Chengqi Decoction (XBCQD) in clinical practice can effectively treat COPD with excessive heat in the lung and fu-organ...

[Clinical Study of Intestinal Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation in Children].

Apr 11, 2022

To observe the clinical characteristics, treatment and prognosis of intestinal acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children ...

Vitamin D Supplementation for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.

Apr 11, 2022

Irritable bowel syndrome (IBS) is a prevalent and complex gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits. Observational studies have suggested a relationshi...

Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice.

Apr 04, 2022

Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea, and emerging evidence has linked dietary components with CDI pathogenesis, suggesting that dietary modulati...

Effect of different dosage of sodium butyrate and niacin on growth, fecal microbiota and vitamin B metabolism in weaned piglets.

Mar 28, 2022

Our study aimed to evaluate the effects of different dosages of sodium butyrate and niacin on the growth performance, fecal vitamin B and microbiota in weaned piglets.Seventy-two weaned piglets (Duroc...

Characterization of diarrheagenic Escherichia coli with special reference to antimicrobial resistance isolated from hospitalised diarrheal patients in Kolkata (2012-2019), India.

Mar 28, 2022

This study analyzes the prevalence and antimicrobial resistance (AMR) of major diarrheagenic Escherichia coli (DEC) pathotypes detected in hospitalized diarrheal patients in Kolkata, India, during 201...

Mesenteric lipoma with small bowel volvulus: A rare cause of upper gastrointestinal obstruction (a case report and literature review).

Mar 14, 2022

Small bowel volvulus due to mesenteric lipoma is a rare clinical entity. It poses both a diagnostic and therapeutic challenge. Small bowel mesenteric lipoma is a rare cause of small bowel obstruction....

Whole genome analysis of rotavirus strains circulating in Benin before vaccine introduction, 2016-2018.

Mar 07, 2022

Species A Rotaviruses (RVA) still play a major role in causing acute diarrhea in children under five years old worldwide. Currently, an 11-gene classification system is used to designate the full geno...

AMC-070: Lenalidomide is Safe and Effective in HIV-associated Kaposi Sarcoma.

Mar 07, 2022

Kaposi sarcoma (KS), an endothelial cell tumor associated with KS-herpesvirus (KSHV), remains among the most common malignancies occurring with HIV infection (HIV-KS). As an oral anti-inflammatory, an...

[Effect of electroacupuncture on gastrointestinal motility in rats with slow transit constipation based on GDNF methylation modification].

Feb 28, 2022

To observe the effect of electroacupuncture (EA) of "Tianshu"(ST25) and "Dachangshu"(BL25) on the intestinal transit function, expression level of glial cell-derived neurotrophic factor (GDNF) and m...

Ghrelin polymorphism/TRPV1 receptor expression in Egyptian IBS patients.

Feb 21, 2022

Irritable bowel syndrome is a functional gastrointestinal disorder. Ghrelin is a peptide hormone which affects gastrointestinal motility. We have studied the association between ghrelin gene polymorph...

Emergency department diagnosis and management of constipation in the United States, 2006-2017.

Feb 14, 2022

Constipation is a common diagnosis in adults and children. Emergency department (ED) visits for constipation increased from 1980 to 2010. Since then, efforts have aimed to reduce resource utilization ...

Chilaiditi syndrome in a Nepalese girl - A potential mislead!

Feb 14, 2022

Chilaiditi's Sign (CS) is a radiological finding on an abdominal radiograph due to colonic interposition between the liver and the diaphragm giving a false impression of free intra peritoneal air. Whe...

Prevalence of Gastrointestinal Symptoms and Irritable Bowel Syndrome Among Individuals With Symptomatic Posttraumatic Stress Disorder.

Jan 31, 2022

Our aim was to describe the prevalence of irritable bowel syndrome (IBS) and other gastrointestinal symptoms in a sample of veterans with posttraumatic stress disorder (PTSD) and to examine the relati...

IBS and the Gut Microflora

Jan 27, 2022

IBS is prevalent in 12% of the global population, but factors contributing to the condition are not well known. Some widely accepted triggers include diet, environment, genetics, and one's gut microfl...