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Irritable Bowel Syndrome / IBS

Transmissible gastroenteritis virus ORF3b up-regulates miR-885-3p to counteract TNF-α production via inhibiting NF-κB pathway.

Aug 12, 2021

Transmissible gastroenteritis (TGE) is an acute viral disease and characterized as severe acute inflammation response that leads to diarrhea, vomiting, and high lethality of piglets. Transmissible gas...

Assessment of Pelvic Floor Function and Quality of Life in Patients Treated for Cervical Cancer: A Multicenter Retrospective Study.

Aug 12, 2021

Our study aimed to evaluate the quality of life (QoL) and pelvic floor function of cervical cancer (CC) patients after treatment.This was a cross-sectional observational cohort study.The participants ...

Gut Microbiome-Derived Uremic Toxin Levels in Hemodialysis Patients on Different Phosphate Binder Therapies.

Aug 12, 2021

Constipation is prevalent in patients with kidney failure partly due to the use of medication, such as phosphate binders. We hypothesized that serum levels of gut microbiome-derived uremic toxins (UTO...

Molecular detection and characterization reveals circulation of multiple genotypes of porcine astrovirus in Haryana, India.

Aug 09, 2021

Porcine astrovirus (PAstV) is distributed worldwide and has been reported to cause diarrhea in pigs. PAstV belongs to the family Astroviridae and genus Mamastrovirus. PAstVs are divided into five dive...

The role of hippocampal glial glutamate transporter (GLT-1) in morphine-induced behavioral responses.

Aug 09, 2021

Opioid abuse modifies synaptic plasticity, which leads to behavioral changes, such as morphine dependence, but the mechanism remains poorly understood. Glial cells play an important role in the modula...

Novel parvovirus in cats, China.

Aug 09, 2021

Parvovirus is a common element of the feline virus group and usually causes gastroenteritis and leukopenia in cats. In this study, we identified a novel protoparvovirus from the Chinese domestic cats,...

Optimization of the Urea Linker of Triazolopyridazine MMV665917 Results in a New Anticryptosporidial Lead with Improved Potency and Predicted hERG Safety Margin.

Aug 05, 2021

Cryptosporidiosis is caused by infection of the small intestine by parasites, resulting in severe diarrhea, dehydration, malabsorption, and potentially death. The only FDA-approved therapeutic is onl...

EFFICACY AND SAFETY OF APREMILAST IN PATIENTS WITH MILD TO MODERATE PLAQUE PSORIASIS: RESULTS OF A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL.

Aug 05, 2021

Patients with mild-to-moderate psoriasis may have substantial quality-of-life impairment.To evaluate apremilast 30 mg BID for mild-to-moderate psoriasis.Phase 3, double-blind, placebo-controlled study...

Ileal fecalomas causing small bowel obstruction: A case report.

Aug 05, 2021

Fecaloma is an accumulation of feces that has formed a mass and has failed to be expelled spontaneously. Because fecal matter is harder and firmer in the left side of colon, and the diameter of the bo...

Accomplishment of probiotics in human health pertaining to immunoregulation and disease control.

Aug 02, 2021

It is a well-established fact that the microbiome harboring the human body plays a critical role in maintaining human health and can influence treatments against various ailments. Human microbiome-bas...

Early onset congenital diarrheas; single center experience.

Aug 02, 2021

Congenital diarrheal disorders (CDDs) are a rare group of enteropathies that typically present in the early few months of life and pose a diagnostic challenge. We aimed to analyze the clinical finding...

A combination of fecal calprotectin and human beta-defensin 2 facilitates diagnosis and monitoring of inflammatory bowel disease.

Jul 29, 2021

Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) show a large overlap in clinical presentation, which presents diagnostic challenges. As a consequence, invasive and burdensome endos...

Giardia duodenalis: Detection by Quantitative Real-Time PCR and Molecular Diversity.

Jul 29, 2021

Conventional microscopy is being progressively replaced by molecular (PCR and Sanger sequencing) methods for the first-line detection, identification, and genotyping of diarrhea-causing enteric parasi...

Structural exploration of Y-domain reveals its essentiality in HEV pathogenesis.

Jul 29, 2021

Hepatitis E virus (HEV) is a major causative agent of hepatitis E infections across the globe. Although the essentiality of HEV nonstructural polyprotein (pORF1) putative Y-domain (Yd) has been establ...

Enteric adenovirus epidemiology from historical fecal samples in Brazil (1998-2005): Pre-rotavirus vaccine era.

Jul 26, 2021

Human adenovirus (HAdV) is recognized as frequent cause of acute gastroenteritis and enteric viruses can be preserved in frozen stored feces for long periods of times. The purpose of the present study...

Multicenter, Observational Study of Lanreotide Autogel for the Treatment of Patients with Neuroendocrine Tumors in Routine Clinical Practice in Germany and Austria.

Jul 26, 2021

The long-acting somatostatin analog lanreotide autogel is effective in the treatment of patients with neuroendocrine tumors.To evaluate the long-term treatment response in patients with neuroendocrine...

Moderate dietary boron supplementation improved growth performance, crude protein digestibility and diarrhea index in weaner pigs regardless to the sanitary condition.

Jul 26, 2021

The study was conducted to investigate the impact of boron supplementation on nutrient digestibility, inflammatory responses, blood metabolites and diarrhea index, and their relevance to growth perfor...

Household Water Insecurity Affects Child Nutrition Through Alternative Pathways to WASH: Evidence From India.

Jul 22, 2021

Household water security matters greatly for child nutrition outcomes in the global South. Water's role in sanitation/hygiene, via diarrheal disease, is cited as a primary mechanism here. Yet, the rel...

Clinical Characteristics and Treatment Response in Microscopic Colitis Based on Age at Diagnosis: A Multicenter Retrospective Study.

Jul 22, 2021

Microscopic colitis (MC) primarily affects older adults; thus, data in younger patients are scarce.To compare clinical characteristics and treatment response by age at diagnosis.This retrospective coh...

A Report of 2 Infant Siblings with Progressive Intrahepatic Familial Cholestasis Type 1 and a Novel Homozygous Mutation in the ATP8B1 Gene Treated with Partial External Biliary Diversion and Liver Transplant.

Jul 22, 2021

BACKGROUND Current treatment options for progressive intrahepatic familial cholestasis type 1 (PFIC-1) comprise ursodeoxycholic acid (UDCA), partial external biliary diversion (PEBD), and liver transp...