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Hematology & Oncology

Gene Therapy Found to Be Promising for β-Thalassemia

CD34+ cells transduced with BB305 vector lowered or eliminated need for red-cell transfusions

Most Smokers With Head and Neck Cancer Have Tried to Quit

Eighty-eight percent of patients had made at least one attempt to quit; mean of 6.6 lifetime attempts

New Drug Combo Ups Survival in HER2/neu Uterine Serous Cancer

Adding intravenous trastuzumab to carboplatin-paclitaxel increased progression-free survival

Cellular Biomedical Tattoo Can ID Hypercalcemia-Linked Cancer

Hypercalcemia linked to cancer can be detected in murine model using cell-based diagnostic system

Marital Status Tied to Earlier Presentation of Melanoma

Being married also tied to likelihood of undergoing SLNB in lesions with Breslow thickness >1 mm

Polypharmacy More Likely for Cancer Survivors

More cancer survivors prescribed five or more unique medications, including those with abuse potential

Males With BRCA Mutations Have Increased Risk of Certain Cancers

Increased incidence of malignant disease, specifically prostate, melanoma, pancreas, breast cancers

Calcium Channel Blockers May Up Pancreatic Cancer Risk in Women

Increased hazard ratios for pancreatic cancer among postmenopausal users of short-acting CCBs

Nonoptimized Drug Therapy Costs More Than $500 Billion Annually

After initial Rx use, average cost of individual having treatment failure, new medical problem over $2,000

Volumetric Laser Endomicroscopy Helps ID Barrett’s Regions

High agreement among reviewers seen in 80 percent of quadrants

TFs Operate Across Gene Loci Within Disease Phenotypes

Epstein-Barr virus EBNA2 protein binds to multiple loci of genome, increasing risk of 7 serious diseases

Adjuvant Pembrolizumab Beneficial in Stage III Melanoma

Pembrolizumab linked to significantly longer recurrence-free survival at 15-month follow-up

Recommendations Developed on Gender Equity in Medicine

ACP supports equitable physician compensation based on comparable work at each stage of career

Adjuvant Pembrolizumab Beneficial in Metastatic NSCLC

And, nivolumab plus ipilimumab linked to better survival in NSCLC with high tumor mutational burden

Adherence to ACS Guidelines Linked to Survival in Colon Cancer

Lower risk of death, improved disease-free survival for ACS guideline score of 5 to 6 versus 0 to 1

Negative Affect That Lingers Tied to Health 10 Years Later

Higher levels of lingering negative affect linked to more chronic conditions, worse functional limitations

Increased Prevalence of Depression, Anxiety After CRC

Older age, being male linked to less anxiety, more depression; less anxiety, depression with marriage

Endocrine Therapy-Induced Alopecia Seen in Breast Cancer

92 percent had grade 1 severity alopecia with endocrine tx; pattern similar to androgenetic alopecia

FDA Warning Ups Hysterectomy Complications for Uterine Fibroids

Complications up following FDA black box warning against use of power morcellation for fibroid excision

Quality of Life Predicts Mortality in Older Breast Cancer Patients

Compared to model with only traditional prognostic variables, one with HRQOL measures performs better

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