Hematology & Oncology

ASH: New Approach to Gene Tx Restores Immune Cells in X-SCID

Efficient vector marking in bone marrow CD34+ cells, myeloid cells, B cells in newly diagnosed SCID

Deceleration in Health Care Spending Growth in 2016

Enrollment trends drove slowdown in Medicaid and private health insurance spending growth in 2016

ASH: High-Dose Gene Transfer Beneficial in Severe Hemophilia A

Factor VIII gene transfer tied to sustained normalization of factor VIII activity levels

ASH: A+AVD Beats ABVD for Advanced Hodgkin’s Lymphoma

Lower combined risk of progression, death, or noncomplete response with A+AVD

ASH: Anti-CD19 CAR T-Cell Tx Beneficial in B-Cell Lymphomas

Second study shows benefit in relapsed or refractory B-cell lymphoma, follicular lymphoma

VDT PACE Effective in Relapsed, Refractory Multiple Myeloma

Minimal response or more in 68.4 percent of patients, partial response or more in 54.4 percent

Breast CA Risk Up With Recent Hormonal Contraceptive Use

Findings from nationwide study in Denmark show small absolute increase in breast cancer risk

Pharmacomechanical Thrombolysis No Benefit in DVT

Addition of pharmacomechanical catheter-directed thrombolysis resulted in higher risk of bleeding

Gene Therapy Shows Beneficial Effect in Men With Hemophilia B

Reduction in annualized bleeding rate and in factor use with infusion of viral vector with transgene

SABCS: Acupuncture Relieves AI-Linked Joint Pain in Breast CA

Greater proportion of patients experiencing a clinically meaningful reduction in worse pain score

SABCS: Two Years of Anastrozole Sufficient in HR+ Early Breast CA

No significant difference in DFS for women receiving anastrozole for two, five years after endocrine tx

Letermovir Prophylaxis Cuts Risk of CMV Infection

Significantly lower risk of clinically significant CMV infection after hematopoietic-cell transplant

Doctors’ Personal Experience of Breast Cancer May Impact Care

Physicians with social network member with poor prognosis more likely to recommend screening

SABCS: Ribociclib Ups PFS in HR+ HER2− Advanced Breast Cancer

Significant improvement in progression-free survival for pre- and perimenopausal women

Educational Video Helps Hairdressers Better ID Melanoma

Significant increase in correct identification of ABCDE criteria for atypical nevi, melanoma detection

Lymph Node Density Predicts Thyroid Cancer Outcomes

Papillary thyroid cancer patients with LND >0.19 have worse disease-specific, overall survival

CVS-Aetna Merger Has Implications for Doctors’ Offices

More health services will likely move out of doctors’ offices to store-based providers

Nivolumab May Induce Successful Depletion of HIV Reservoir

Case report describes smoker with HIV infection receiving nivolumab for non-small-cell lung cancer

Oral Microbiome Composition Linked to Esophageal Cancer Risk

Periodontal pathogen Tannerella forsythia linked to increased risk of esophageal adenocarcinoma

Ceruloplasmin ID’d As Marker of Kidney Disease in Sickle Cell

Findings part of proteomic analysis of urine in patients with sickle cell disease

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