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Hematology & Oncology

Histamine May Play Role in Colorectal Tumorigenesis

Histamine-producing probiotic reduces inflammation, suppresses colon tumors in mice

Naloxegol Has No Effect on Opioid Dose in Opioid-Tied Constipation

Centrally-mediated analgesia was maintained during treatment with naloxegol in noncancer pain, OIC

General, Central Obesity Linked to Specific Breast Cancer Risk

General obesity, indicated by BMI, more strongly linked to ER+/PR+ subtype

Insurer Market Power Lowers Providers’ Prices

Evidence seen for specialists in markets with high provider, insurer concentration

Extended Thromboprophylaxis Safe, Effective After Liver Surgery

Severe complication rate 5.6 percent, with no 90-day mortalities

Monthly Feedback Linked to Improved Colonoscopy Quality

But no improvement observed with quarterly feedback

ACP Does Not Support Legalization of Assisted Suicide

Legalization would affect trust in the patient-physician relationship, and in the medical profession

New Link Seen Between Gene Fusion and Bladder Cancer

Previously overlooked section of fusion found to negatively impact cancer cells, researchers say

PD-L1 Mainly Expressed in Metastatic CRC Lesions

Overall, 81.8 percent of metastatic CRCs and 40.9 percent of primary lesions had PD-L1 expression

Expected Burden of Lung Cancer High for People Living With HIV

PLWH who adhere to antiretroviral tx but smoke are substantially more likely to die from lung cancer

Are Physicians Obligated to Help on Planes?

One administrative physician explains his sense of obligation to help

Physicians Tweeting About Drugs May Have Conflict of Interest

Physicians with financial conflict of interest often mention specific drugs for which they have a conflict

‘Science Spin’ Found Prevalent in Biomedical Literature

Nature of spin varies, with highest variability in prevalence of spin seen in trials

FDA Approves Aliqopa for Follicular Lymphoma

Aliqopa, a kinase inhibitor, blocks several enzymes that promote cell growth

EHR Data May Beat Claims Data in Assessing Sepsis Incidence

Based on clinical data, no change seen in incidence of sepsis, combined outcome of death or discharge

Doctors Spend Almost Six Hours Per Day on EHR Tasks

Clerical and administrative tasks including order entry, billing account for almost half of hours

Skin Cancer Prevention Strategies Needed in Work Settings

High occupational UV exposure tied to two-fold increase in skin cancer risk

Fibrous Dysplasia Associated With Increased Breast Cancer Risk

Breast cancer risk is more than three times as high in FD patients as in the general population

Mutational Signatures Can More Accurately ID MMR Deficiency

Mutational signatures better report mismatch repair deficiency than sequencing of MMR genes

Caffeine Tied to Lower Mortality in Women With Diabetes

Women who consumed caffeine from coffee had reduced risk of all-cause, cardiovascular deaths

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