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Ovarian Cancer

Evolutionary dynamics of cancer multidrug resistance in response to olaparib and photodynamic therapy.

Aug 23, 2021

P-glycoprotein (P-gp) is an adenosine triphosphate (ATP)-dependent drug efflux protein commonly associated with multidrug resistance in cancer chemotherapy. In this report, we used a dual-fluorescent ...

COVID-19 Experiences Predicting High Anxiety and Depression Among a Sample of BRCA1/BRCA2-positive Women in the US.

Aug 19, 2021

During the COVID-19 pandemic, breast and ovarian cancer survivors experienced more anxiety and depression than before the pandemic. Studies have not investigated the similarities of this trend among ...

Non-invasive evaluation of HABP1 expression with Tc-labeled small-interference RNA in ovarian cancer.

Aug 19, 2021

Ovarian cancer is one of the most common gynecological cancers in women with a low 5-year survival rate. Evaluation of hyaluronic acid binding protein 1 (HABP1) level can provide important information...

LncRNA SRA mediates cell migration, invasion, and progression of ovarian cancer via NOTCH signaling and epithelial-mesenchymal transition.

Aug 19, 2021

Long non-coding RNA (lncRNA) is a newly identified regulator of tumor formation and tumor progression. The function and expression of lncRNAs remain to be fully elucidated, but recent studies have beg...

Response to olaparib in metastatic lung adenocarcinoma with germline BRCA2 mutation: a case report.

Aug 16, 2021

Mutation of BRCA2, a breast cancer susceptibility gene, is associated with the development of breast and ovarian cancer. Olaparib is an oral poly-adenosine diphosphate-ribose polymerase (PARP) inhibit...

Symptom clusters in 1330 survivors of 7 cancer types from the PROFILES registry: A network analysis.

Aug 16, 2021

Research into the clustering of symptoms may improve the understanding of the underlying mechanisms that affect survivors' symptom burden. This study applied network analyses in a balanced sample of c...

Fear, worry and sadness: an exploratory study of psychological wellbeing in men caring for their partner with ovarian cancer.

Aug 16, 2021

Ovarian cancer is the leading cause of death from female cancers in Australia with the majority of women presenting with advanced disease. The burden of caregiving is largely borne by male carers; how...

Preeclampsia and cancer risk in women in later life: a systematic review and meta-analysis of cohort studies.

Aug 12, 2021

Results of this work may provide some guidance for subsequent ovarian cancer screening in women with preeclampsia and provide new directions for future studies.This study investigated the difference i...

Dysfunctional activity of classical DNA end-joining renders acquired resistance to carboplatin in human ovarian cancer cells.

Aug 12, 2021

Ovarian cancer is the deadliest gynecological malignancy worldwide. Although chemotherapy is required as the most standard treatment strategy for ovarian cancer, the survival rates are very low, large...

Sexual dysfunction in Thai gynecologic malignancies survivors: A single-institutional cross-sectional observational survey.

Aug 12, 2021

To examine the prevalence of female sexual dysfunction (FSD) in gynecologic cancer survivors.A cross-sectional observation survey recruited women aged 18-65 years old who were diagnosed with gynecol...

An In-Depth Review of Niraparib in Ovarian Cancer: Mechanism of Action, Clinical Efficacy and Future Directions.

Aug 09, 2021

Niraparib is an oral, potent, highly selective poly-ADP ribose polymerase 1 (PARP1) and PARP2 inhibitor. In most developed countries, it is approved as a maintenance treatment for epithelial ovarian,...

Loss of KLF9 facilitates stemness in ovarian cancer ascites-derived multicellular spheroids via Notch1/Slug signaling.

Aug 09, 2021

The ascites that develops in advanced ovarian cancer (OC), both at diagnosis and upon recurrence, is a rich source of multi-cellular spheroids/aggregates (MCSs/MCAs), which are the major seeds of tumo...

Chemotherapy with or without avelumab followed by avelumab maintenance versus chemotherapy alone in patients with previously untreated epithelial ovarian cancer (JAVELIN Ovarian 100): an open-label, randomised, phase 3 trial.

Aug 09, 2021

Although most patients with epithelial ovarian cancer respond to frontline platinum-based chemotherapy, around 70% will relapse within 3 years. The phase 3 JAVELIN Ovarian 100 trial compared avelumab ...

Impact of Surgeon Type and Rurality on Treatment and Survival of Ovarian Cancer Patients.

Aug 05, 2021

National Comprehensive Cancer Network guidelines recommend ovarian cancer patients receive cancer-directed surgery from a gynecologic oncologist surgeon. We aimed to determine if rurality impacts type...

Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer.

Aug 05, 2021

Each patient's cancer consists of multiple cell subpopulations that are inherently heterogeneous and may develop differing phenotypes such as drug sensitivity or resistance. A personalized treatment r...

Development and in vitro characterisation of an induced pluripotent stem cell model of ovarian cancer.

Aug 05, 2021

Ovarian cancer recurs despite advances in treatment and is due to drug resistance. The persistence of cancer stem cells (CSCs) is one of the causes. It has been challenging to maintain CSCs long term ...

Ovarian cancer surveillance in the clinical follow up of women with known BRCA1 or BRCA2 pathogenic variants in a large health care system.

Aug 02, 2021

To assess CA 125 and transvaginal ultrasound surveillance in women with BRCA1 or BRCA2 pathogenic variants in a pragmatic clinical setting with>1 year follow up.Retrospective cohort study in a larg...

Ambient air pollution and ovarian cancer survival in California.

Aug 02, 2021

To examine whether exposure to ambient ozone, particulate matter with diameter less than 2.5 μm (PM), nitrogen dioxide (NO), and distance to major roadways (DTR) impact ovarian cancer-specific surviv...

PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.

Aug 02, 2021

Polyguanine tracts (PolyGs) are short guanine homopolymer repeats that are prone to accumulating mutations when cells divide. This feature makes them especially suitable for cell lineage tracing, whic...

A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer.

Jul 29, 2021

Positive ascites cytology is a strong prognostic factor in patients with early-stage ovarian cancer (OvCa). However, limited information is currently available on the impact of positive ascites cytolo...

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