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Infectious Disease General

Nitroxoline Activity in Antifungal-Resistant Candida Species Isolated from the Urinary Tract in Vitro

May 26, 2022

Drug-resistant fungus infections were becoming more common worldwide, yet only a few new antifungals were being produced. The ancient antibacterial nitroxoline was used to treat bacterial urinary trac...

Impact of Clopidogrel on Clinical Outcomes in Staphylococcus Aureus Bacteremia Patients

May 26, 2022

Antimicrobial action of activated platelets against Staphylococcus aureus was known. Thrombocytopenia and higher patient mortality could be caused by S. aureus-induced platelet clearance. In a large n...

Pharmacokinetics & Dose Optimization Strategies of Para-Aminosalicylic Acid in RR-TB Children

May 26, 2022

Rifampicin-resistant tuberculosis (RR-TB) therapy choices for children were limited, and para-aminosalicylic acid (PAS) remained an important component of treatment regimens. PAS's ability to prevent ...

Heavily Treatment-Experienced Adults Living with Multidrug-Resistant HIV-1: Genotypic & Phenotypic Results

May 26, 2022

In phase 3 BRIGHTE research, fostemsavir plus optimal background therapy (OBT) resulted in sustained rates of virologic suppression for 96 weeks in highly treated persons with multidrug-resistant HIV-...

Enterococcus faecium in Response to a Combination of Daptomycin & Fosfomycin Reveals Adaptive Strategies

May 26, 2022

Vancomycin-resistant Enterococcus faecium (VREfm) infections were a major public health concern. The front-line antibiotic daptomycin (DAP) had become increasingly resistant to VREfm isolates. As a re...

Antiviral Activity of Remdesivir & GS-441524 Against Delta, Omicron, & Other SARS-CoV-2 Variants

May 26, 2022

Multiple variations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had emerged and spread rapidly across the pandemic, with Omicron being the most prevalent version now circulatin...

Common & Rare Genetic Markers of SLIDs Resistance in Mycobacterium Tuberculosis

May 26, 2022

Resistance to the second-line injectable medicines (SLIDs) amikacin (AMK), capreomycin (CAP), and kanamycin (KAN) was known to be conferred by point mutations in the rrs gene and the eis promoter. Whi...

Safety of iABLC as Antifungal Prophylaxis in Lung Transplant Recipients

May 26, 2022

The most extensively used antifungal preventive medicines in lung transplant recipients have inhaled forms of amphotericin B, but there was minimal data on their safety. Researchers conducted a single...

The Effect of Rifampicin on Darunavir, Ritonavir, & DTG Exposure Within PBMCs

May 26, 2022

The induction of metabolizing enzymes and efflux transporters mediated by rifampicin (Rif) affected ritonavir-boosted darunavir (DRV/r) and dolutegravir (DTG). It affected the treatment of tuberculosi...

Unbound Ceftriaxone in Critically Ill Patients: A Multicenter Population Pharmacokinetic Study

May 26, 2022

For a study, researchers sought to determine optimal dosing regimens by describing the total and unbound population pharmacokinetics of ceftriaxone in critically ill adult patients. About 2  pharmaco...

Gene Amplification of CYP51B: Mechanism of Resistance to Azole Compounds in Trichophyton indotineae

May 26, 2022

For a study, researchers sought to figure out how T. indotineae strains respond to itraconazole (ITC) and voriconazole (VRC). The study included 2 azole-sensitive strains (ITC MIC<0.125 g/mL; VRC M...

Islatravir: High Barrier to Resistance & Differentiated Resistance Profile from Approved NRTIs

May 26, 2022

Islatravir (ISL) was a nucleoside reverse transcriptase translocation inhibitor (NRTTI) that blocked reverse transcriptase (RT) translocation on the primer: template, inhibiting HIV reverse transcript...

Missed Vaccination Opportunities for Invasive Pneumococcal Disease

May 25, 2022

Over half of patients with invasive pneumococcal disease (IPD) had a missed opportunity to be vaccinated within our healthcare system prior to developing IPD. Invasive pneumococcal disease (IPD...

Extensive eczema herpeticum in a previously well child.

May 23, 2022

Eczema herpeticum, also known as Kaposi varicelliform eruption, is a potentially life-threatening disseminated cutaneous viral infection. In the majority of cases, this condition develops as a complic...

ILDR1 promotes influenza A virus replication through binding to PLSCR1.

May 23, 2022

As a natural antiviral regulator, phospholipid scramblase 1 (PLSCR1) has been shown to inhibit influenza virus replication in infected cells through interacting with NP of influenza A virus (IAV). But...

Myxovirus resistance protein A for discriminating between viral and bacterial lower respiratory tract infections in children - The TREND study.

May 23, 2022

Discriminating between viral and bacterial lower respiratory tract infection (LRTI) in children is challenging, leading to an excessive use of antibiotics. Myxovirus resistance protein A (MxA) is a pr...

activates the host RIDD pathway to subvert BLOS1-directed immune defense.

May 23, 2022

The phagocytosis and destruction of pathogens in lysosomes constitute central elements of innate immune defense. Here, we show that , the causative agent of brucellosis, the most prevalent bacterial z...

The First Case of Coxiella Burnetti Infection Detected Through Bone Marrow Biopsy in Vietnam.

May 23, 2022

is an obligate intracellular bacterium that causes the zoonotic infectious disease, Q fever. The common clinical presentation is fever, hepatitis, and pneumonia; laboratory examination could reveal p...

How to Best Prevent Central Line-Associated Bloodstream Infections

May 18, 2022

The following was originally posted to the University of Nebraska Medical Center Division of Infectious Diseases blog.     Dr. Rupp recently assisted in the creation of ne...

Complication of Coronary Vasospasm: Ergotamine, Cobicistat, & Darunavir

May 17, 2022

Ergotism is an uncommon cause of peripheral vasoconstriction that manifests differently depending on the arteries involved. Coronary vasospasm is an uncommon and possibly dangerous symptom of ergotism...