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HIV/AIDS

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion.

Feb 11, 2020

Ataxia, causing imbalance, dizziness and falls, is a leading cause of neurological disability. We have recently identified a biallelic intronic AAGGG repeat expansion in replication factor complex sub...

Technological challenges in the preclinical development of an HIV nanovaccine candidate.

Feb 11, 2020

Despite a very active research in the field of nanomedicine, only a few nano-based drug delivery systems have reached the market. The "death valley" between research and commercialization has been par...

New Potential Axes of HIV Neuropathogenesis with Relevance to Biomarkers and Treatment.

Feb 11, 2020

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) affect approximately half of people living with HIV despite viral suppression with antiretroviral therapies and represent ...

Lymphocytic Interstitial Pneumonia and Follicular Bronchiolitis in Children

Feb 11, 2020

Pediatric lymphocytic interstitial pneumonia (LIP) and follicular bronchiolitis (FB) are poorly characterized lymphoproliferative disorders. We present and quantify demographics, radiological and hist...

Addition of Maraviroc Versus Placebo to Standard Antiretroviral Therapy for Initial Treatment of Advanced HIV Infection: A Randomized Trial.

Feb 11, 2020

Patients diagnosed with advanced HIV infection have a poor prognosis despite initiation of combined antiretroviral therapy (c-ART).To assess the benefit of adding maraviroc, an antiretroviral drug wit...

Aerosol Delivery of Synthetic mRNA to Vaginal Mucosa Leads to Durable Expression of Broadly Neutralizing Antibodies against HIV.

Jan 30, 2020

There is a clear need for low-cost, self-applied, long-lasting approaches to prevent human immunodeficiency virus (HIV) infection in both men and women, even with the advent of pre-exposure prophylaxi...

Kaposi's sarcoma in a HIV-positive patient: an exuberant and widespread case report in the Amazon.

Jan 23, 2020

A 37-year-old male patient, Fitzpatrick skin phototype IV, a student living in Belem, Amazon region, in 2015 had a confirmed diagnosis of acquired immunodeficiency virus (HIV) infection, but did not i...

The seroprevalence of HIV in patients undergoing lower limb Total Joint Arthroplasty (TJA) in South Africa.

Jan 23, 2020

The aim was to assess the seroprevalence of Human Immunodeficiency Virus (HIV) in non-haemophilic patients undergoing primary Total Joint Arthroplasty (TJA) at an academic hospital in South Africa.A r...

Incarceration and Number of Sexual Partners After Incarceration Among Vulnerable US Women, 2007-2017.

Jan 23, 2020

s. To examine whether women's incarceration increases numbers of total and new sexual partners. US women with or at risk for HIV in a multicenter cohort study answered incarceration and sexual partner...

A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV.

Jan 23, 2020

Transcriptional programming of the innate immune response is pivotal for host protection. However, the transcriptional mechanisms that link pathogen sensing with innate activation remain poorly unders...

CHARACTERISTICS OF GRAVES' DISEASE IN HIV-INFECTED PATIENTS ON ANTIRETROVIRAL THERAPY.

Jan 23, 2020

To demonstrate clinical and laboratory characteristics of Graves' disease in human immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART). : This is a single-institution study...

HIV Infection & Cancer Outcomes Among the Elderly

Jan 21, 2020

Despite treatment, elderly patients with cancer who are HIV-positive had worse outcomes than those without the infection in a recent study.   Previous research has shown that mortality ...

Immunologic Non-Response Despite Viral Suppression

Jan 03, 2020

For HIV-positive individuals who begin antiretroviral therapy (ART) at CD4 counts below 500 cells/mm3, immunologic non-response has been shown in prior research to be associated with increased risk fo...

CME - Conference Highlights: IDWeek 2019

Dec 20, 2019

This course discusses the key findings of five studies presented at the 2019 joint annual meeting of the Infectious Diseases Society of America, Society for Healthcare Epidemiology of America, the HIV...