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Infectious Disease

Childhood & Parental Vaccination Impact on SARS-CoV-2 Infection Rates in Children

Oct 19, 2022

Analyses to evaluate the efficacy of COVID-19 vaccinations are limited, and there is a lack of evidence on the indirect protection of children through the immunization of household members. Prior to r...

Tenofovir: Minimal Cross-resistance in Children & Teens

Oct 19, 2022

Dolutegravir (DTG) in combination with tenofovir disoproxil fumarate (TDF) and lamivudine (3TC) is a fixed-dose combination that has been shown to increase adherence and has a good resistance profile....

Online Symptom Checkers Often Not Accurate for ID'ing Skin Rashes

Oct 19, 2022

TUESDAY, Oct. 18, 2022 (HealthDay News) -- Online symptom checkers are often inaccurate in identifying skin rashes, according to a study published online Oct. 12 in the Journal of the American Academy...

Early Anti-Anaerobic Antibiotics May Worsen Outcomes in Critically Ill

Oct 19, 2022

TUESDAY, Oct. 18, 2022 (HealthDay News) -- Early administration of anti-anaerobic antibiotics is associated with an increased risk for mortality among critically ill patients, according to a study pub...

Clinically Undetected Bacteremia in ED-Discharged Children

Oct 18, 2022

In spite of recent improvements in the prevention of invasive infections, bacteremia in infants and toddlers continues to be a major problem. This study's primary objective was to characterize the dem...

Clinical Features, AMR, & NTS Serogroups Isolated From Infants Less Than 3 Months Old

Oct 18, 2022

Infants with nontyphoidal Salmonella (NTS) enterocolitis should be treated with antibiotics. However, it is unclear if newborns have a problem with antimicrobial resistance (AMR). This research aimed ...

P. Vivax Infection, Breastfeeding, & Malaria in Childhood

Oct 18, 2022

A clinical case of malaria is detected, treated, and reported on relatively few Amazonian newborns before their first birthday. This may be because Amazonian infants are rarely exposed to an infection...

#VisualAbstract: Cefepime/enmetazobactam superior to piperacillin/tazobactam for the treatment of complicated urinary tract infections and acute pyelonephritis

Oct 15, 2022

1. In this randomized controlled trial, treatment of acute pyelonephritis and complicated urinary tract infection caused by gram-negative organisms with cefepime/enmetazobactam met the criteria fo...

Glucocorticoid therapy may not be efficacious for pediatric COVID-19 without MIS-C

Oct 15, 2022

1. Hospital length of stay did not differ for children who received early steroids for COVID without non-multisystem inflammatory syndrome compared to those who did not receive early steroids Evidence...

Optimized vitamin C levels may be associated with mitigated HPV infection risk

Oct 15, 2022

1. Though not statistically significant, there was a U-shaped found between vitamin C levels and HPV infection risk, with women having inadequate, or saturated levels of vitamin C sharing higher HPV r...

Weight Gain & the Incidence of Cardiometabolic Conditions

Oct 14, 2022

People living with HIV-1 (PLWH) often gain weight while taking antiretroviral therapy (ART), but it is unclear whether this weight gain is linked to negative metabolic or cardiovascular outcomes in th...

Cirrhosis/Advanced Fibrosis in HBsAg-Negative & HBcAb-Positive Adults

Oct 13, 2022

HBsAg-negative patients (hepatitis B surface antigen-negative) and HBcAb-positive (hepatitis B core antibody-positive) may be missed for cirrhosis evaluation in the clinic. Here, the researchers asses...

FDA Approves Boostrix for Third-Trimester Administration

Oct 13, 2022

WEDNESDAY, Oct. 12, 2022 (HealthDay News) -- The U.S. Food and Drug Administration has approved Boostrix for immunization during the third trimester of pregnancy to prevent pertussis in infants younge...

Sepsis Clinical Subphenotype Identification

Oct 13, 2022

The clinical illness known as sepsis encompasses a wide range of variations. A more targeted approach to treatment may be possible after sepsis subphenotypes have been identified. However, there aren'...

Clinical Utility of Circulating Pneumoproteins in COVID-19

Oct 13, 2022

This meta-analysis looked at the role of circulating pneumo proteins in the detection, severity, and prognosis of COVID-19. The researchers combed through five database systems and a variety of other ...

Impact of C/T vs. Best Alternative Therapy on Clinical Outcomes in Patients

Oct 13, 2022

Pseudomonas aeruginosa infections that are MDR (multidrug-resistant), XDR (extensively drug-resistant), or DTR (difficult-to-treat) are becoming increasingly difficult to treat. Treatment of MDR and X...

Patient-Reported Outcomes (PROs) in HIV Infection

Oct 12, 2022

This research aimed to determine whether PROs (patient-reported outcome measures) should be utilized with HIV-positive individuals (PLHIV). To assist in deciding which assertions ought to be substanti...

Cefepime/Enmetazobactam Noninferior for Complicated UTI

Oct 12, 2022

TUESDAY, Oct. 11, 2022 (HealthDay News) -- For patients with complicated urinary tract infection (UTI) or acute pyelonephritis caused by gram-negative pathogens, cefepime/enmetazobactam is noninferior...

Early oseltamivir associated with improved influenza outcomes in hospitalized children

Oct 11, 2022

1. In a large retrospective cohort of hospitalized children with influenza, those who received oseltamivir within one day of admission had significantly shorter length of stay and lower 7-day readmiss...

Bivalent COVID-19 booster has a similar safety profile and efficacy at preventing infection as compared to previous vaccines

Oct 11, 2022

1. The bivalent omicron-containing coronavirus 2019 disease (COVID-19) vaccine has a similar safety profile to previous mRNA vaccinations.  2. The bivalent vaccine also elicits a noninferior immunoge...